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Titolo:
ISOTOPIC BEAT PATTERNS IN FOURIER-TRANSFORM ION-CYCLOTRON RESONANCE MASS-SPECTROMETRY - IMPLICATIONS FOR HIGH-RESOLUTION MASS MEASUREMENTS OF LARGE BIOPOLYMERS
Autore:
HOFSTADLER SA; BRUCE JE; ROCKWOOD AL; ANDERSON GA; WINGER BE; SMITH RD;
Indirizzi:
BATTELLE MEM INST,PACIFIC NW LABS,DEPT CHEM SCI,CHEM METHODS & SEPARAT GRP,POB 999,MS P8-19 RICHLAND WA 99352 BATTELLE MEM INST,PACIFIC NW LABS,DEPT CHEM SCI,CHEM METHODS & SEPARAT GRP,POB 999,MS P8-19 RICHLAND WA 99352 EXTRE FTMS MADISON WI 53711
Titolo Testata:
International journal of mass spectrometry and ion processes
fascicolo: 1-2, volume: 132, anno: 1994,
pagine: 109 - 127
SICI:
0168-1176(1994)132:1-2<109:IBPIFI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROSPRAY-IONIZATION; MAGNETIC-FIELD; PENNING TRAP; CELL; ELECTROPHORESIS; REMEASUREMENT; BIOMOLECULES; MOLECULES; INTERFACE; MECHANISM;
Keywords:
FOURIER TRANSFORM ION CYCLOTRON RESONANCE; TIME DOMAIN SIGNALS; ISOTOPE DISTRIBUTION; ELECTROSPRAY; HIGH RESOLUTION MASS MEASUREMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Hofstadler et al., "ISOTOPIC BEAT PATTERNS IN FOURIER-TRANSFORM ION-CYCLOTRON RESONANCE MASS-SPECTROMETRY - IMPLICATIONS FOR HIGH-RESOLUTION MASS MEASUREMENTS OF LARGE BIOPOLYMERS", International journal of mass spectrometry and ion processes, 132(1-2), 1994, pp. 109-127

Abstract

Fourier transform ion cyclotron resonance (FTICR) mass spectrometry time domain signals from multiply charged biopolymer ions exhibit characteristic and predictable beat patterns due to the closely spaced cyclotron frequencies of the various isotopic constituents. Isotope beat fequencies can readily and accurately be predicted from the difference in cyclotron frequencies of neighbouring isotope peaks. The nature of these signals has important implications for high resolution mass analysis, particularly in instances where rapid spectral acquisition is desirable such as with on-line analysis of chromatographic/electrophoretic effluents. Due to the pulsed nature of the frequency information inthese transients, resolution improvements are effectively realized ina stepwise nature. As will be demonstrated, the application of apodization functions can have deleterious effects on signal-to-noise and resolution when beats are present only near the beginning and end of thetransient. Additionally, in instances where the length of FTICR data acquisition is critical (such as in conjunction with on-line separations or in the analysis of very high molecular weight species), it is crucial to choose data acquisition parameters based on the predicted behavior of the time domain signal for the efficient and accurate acquisition of mass spectra.

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Documento generato il 12/07/20 alle ore 06:50:19