Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANGIOPEPTIN INHIBITS ONCOGENE INDUCTION IN RABBIT AORTA AFTER BALLOONDENUDATION
Autore:
BAUTERS C; VANBELLE E; WERNERT N; DELCAYRE C; THOMAS F; DUPUIS B; LABLANCHE JM; BERTRAND ME; SWYNGHEDAUW B;
Indirizzi:
HOP CARDIOL,SERV CARDIOL B & HEMODYNAM,BLVD PROF J LECLERCQ F-59037 LILLE FRANCE UNIV LILLE,DEPT CARDIOL LILLE FRANCE UNIV LILLE,DEPT PHARMACOL LILLE FRANCE UNIV LILLE,DEPT PATHOL LILLE FRANCE INSERM,U127 PARIS FRANCE IPSEN BIOTECH PARIS FRANCE
Titolo Testata:
Circulation
fascicolo: 5, volume: 89, anno: 1994,
pagine: 2327 - 2331
SICI:
0009-7322(1994)89:5<2327:AIOIIR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CORONARY ANGIOPLASTY; MYOINTIMAL PROLIFERATION; PROTOONCOGENE EXPRESSION; INTIMAL HYPERPLASIA; GROWTH-FACTORS; ANTISENSE RNA; C-MYC; FOS; RESTENOSIS;
Keywords:
RESTENOSIS; ARTERIES; ONCOGENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C. Bauters et al., "ANGIOPEPTIN INHIBITS ONCOGENE INDUCTION IN RABBIT AORTA AFTER BALLOONDENUDATION", Circulation, 89(5), 1994, pp. 2327-2331

Abstract

Background Angiopeptin, a synthetic cyclic octapeptide analogue of somatostatin, reduces neointimal hyperplasia after balloon denudation ofrabbit aorta if administered before injury. The aim of this study wasto analyze the effect of angiopeptin pretreatment on the lever of expression of the c-fos and c-jun protooncogenes, early markers of smoothmuscle cell proliferation, after balloon denudation of rabbit aorta. Methods and Results For histological analysis of the effect of angiopeptin on neointimal thickening after aortic balloon denudation, rabbitswere randomized into three groups: group 1 (controls), twice-daily injections of saline begun 24 hours before balloon denudation (n=9); group 2, twice-daily injections of angiopeptin 10 mu g/kg begun 24 hours before balloon denudation (n=9); and group 3, twice-daily injections of angiopeptin 10 mu g/kg begun 1 hour after balloon denudation (n=7). The degree of neointimal thickening 28 days after balloon denudation was significantly less in group 2 than in group 1 (neointimal area: group 1, 0.59+/-0.11 mm(2); group 2, 0.22+/-0.05 mm(2); P<.05. Neointima/media: group 1, 0.85+/-0.17; group 2, 0.23+/-0.05; P<.05). When angiopeptin was started 1 hour after denudation (group 3), however, the neointimal area (0.52+/-0.09 mm(2)) and the neointima/media ratio (0.7+/-0.10) were not statistically different from the control group. For analysis of protooncogene induction, rabbits received twice-daily subcutaneous injections of saline (n=7), angiopeptin 10 mu g/kg (n=8), or angiopeptin 100 mu g/kg (n=4) begun 24 hours before balloon denudation. The animals were killed 30 minutes after balloon denudation, and total aortic RNA was hybridized with fos and jun probes. Expression of c-fos and c-jun was detected 30 minutes after injury; angiopeptin pretreatment at 20 mu g . kg(-1) . d(-1) induced a 41% reduction in c-fos expression and a 42% reduction in c-jun expression compared with control animals. The inhibitory effect at the higher dose of angiopeptin was similar. Conclusions Our results show that the inhibitory effect of angiopeptin on neointimal thickening is related to events that occur very early after injury and suggest that the inhibition of smooth muscle cellactivation may be responsible, at least in part, for this effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:25:35