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Titolo:
EFFECT OF L364.718 DURING SUCKLING ON THE SENSITIVITY TO THE HYPOPHAGIC EFFECT OF CHOLECYSTOKININ IN ADULT-RATS
Autore:
VOITS M; RODEL S; FORSTER S; PLAGEMANN A; FINK H;
Indirizzi:
HUMBOLDT UNIV BERLIN,FAC MED CHARITE,INST PHARMACOL & TOXICOL,CLARA ZETKIN STR 94 D-10098 BERLIN GERMANY HUMBOLDT UNIV BERLIN,FAC MED CHARITE,INST EXPT ENDOCRINOL D-10098 BERLIN GERMANY
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 1, volume: 21, anno: 1997,
pagine: 183 - 192
SICI:
0278-5846(1997)21:1<183:EOLDSO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-INTAKE; POSTNATAL-DEVELOPMENT; CCK RECEPTORS; BRAIN REGIONS; INHIBITION; PEPTIDES; ONTOGENY; HORMONES; GUT; SEX;
Keywords:
CCK-A RECEPTOR; CCK-8S; CHOLECYSTOKININ; FOOD INTAKE; L-364.718; POSTNATAL DEVELOPMENT; RAT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Voits et al., "EFFECT OF L364.718 DURING SUCKLING ON THE SENSITIVITY TO THE HYPOPHAGIC EFFECT OF CHOLECYSTOKININ IN ADULT-RATS", Progress in neuro-psychopharmacology & biological psychiatry, 21(1), 1997, pp. 183-192

Abstract

1. In the present study it was investigated whether drugs acting at the cholecystokinin (CCK)-A receptor given to rat pups may result in long-lasting changes in body weight or regulation of food intake controlled by CCK. 2. From day 3 to day 10 of Life, male and female Wistar rat pups were treated with the CCK-A receptor antagonist L-364.718 and the CCK-A+B agonist CCK-8S. 3. In adult rats, treated with L364.718 during suckling, the sensitivity to the acute hypophagic action of CCK-8Swas weaker or abolished compared to adults treated with saline duringsuckling. In adult rats given CCK-8S during suckling acute treatment with CCK-8S reduced food intake to the same extent as in the group treated with saline postnatally. 4. These data show that early postnatal treatment with the CCK-A receptor antagonist L364.718 has an impact onthe hypophagic response to CCK-8S in later life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:50:44