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Titolo:
ALTERATIONS IN NF-KAPPA-B REL FAMILY PROTEINS IN SPLENIC T-CELLS FROMTUMOR-BEARING MICE AND REVERSAL FOLLOWING THERAPY/
Autore:
GHOSH P; SICA A; YOUNG HA; YE JP; FRANCE JL; WILTROUT RH; LONGO DL; RICE NR; KOMSCHLIES KL;
Indirizzi:
NCI,FREDERICK CANC RES & DEV CTR,EXPTL IMMUNOL LAB,BLDG 560,RM 31-16BFREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,MOLEC VIROL & CARCINOGENESIS LAB,ABLBASIC RES PROGRAM FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BIOL CARCINOGENESIS & DEV PROGRAM FREDERICK MD 21702
Titolo Testata:
Cancer research
fascicolo: 11, volume: 54, anno: 1994,
pagine: 2969 - 2972
SICI:
0008-5472(1994)54:11<2969:AINRFP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE RENAL-CANCER; ACID; IL-2; EXPRESSION; CARCINOMA; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Ghosh et al., "ALTERATIONS IN NF-KAPPA-B REL FAMILY PROTEINS IN SPLENIC T-CELLS FROMTUMOR-BEARING MICE AND REVERSAL FOLLOWING THERAPY/", Cancer research, 54(11), 1994, pp. 2969-2972

Abstract

It has recently been shown that T-cell signal transduction molecules are altered in tumor-bearing mice. We have examined the expression of NF kappa B/Rel family proteins in T-cells from mice bearing Renca, a murine renal carcinoma. T-cells from Renca-bearing mice expressed undetectable levels of nuclear c-Rel, NF kappa B p65, and p50; however two shorter forms of p50 (p48 and p46), truncated at the NH2-terminus, were present exclusively in the nucleus and were able to bind DNA. These T-cells have reduced expression of gamma-interferon mRNA. In mice successfully treated with flavone 8-acetic acid and recombinant human interleukin 2, the T-cells expressed normal levels of all three nuclear NFkappa B/Rel proteins. These results suggest that alterations in transcription factors may accompany changes in signal transduction molecules in T-cells from tumor-bearing animals; however, the changes are reversed with successful biological therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:15:20