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Titolo:
PLASMID-BORNE CADMIUM RESISTANCE GENES IN LISTERIA-MONOCYTOGENES ARE SIMILAR TO CADA AND CADC OF STAPHYLOCOCCUS-AUREUS AND ARE INDUCED BY CADMIUM
Autore:
LEBRUN M; AUDURIER A; COSSART P;
Indirizzi:
INST PASTEUR,GENET MOLEC LISTERIA LAB,CNRS,URA 1300,28 RUE DR ROUX F-75724 PARIS 15 FRANCE INST PASTEUR,GENET MOLEC LISTERIA LAB,CNRS,URA 1300 F-75724 PARIS 15 FRANCE FAC MED TOURS,BACTERIOL LAB F-37032 TOURS FRANCE INRA,PATHOL INFECT & IMMUNOL LAB F-37380 NOUZILLY FRANCE
Titolo Testata:
Journal of bacteriology
fascicolo: 10, volume: 176, anno: 1994,
pagine: 3040 - 3048
SICI:
0021-9193(1994)176:10<3040:PCRGIL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
P-TYPE ATPASE; ESCHERICHIA-COLI; ALCALIGENES-EUTROPHUS; CANDIDATE GENE; MENKES DISEASE; PROKARYOTIC METALLOTHIONEIN; NUCLEOTIDE-SEQUENCE; RHIZOBIUM-MELILOTI; STRUCTURAL GENES; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
M. Lebrun et al., "PLASMID-BORNE CADMIUM RESISTANCE GENES IN LISTERIA-MONOCYTOGENES ARE SIMILAR TO CADA AND CADC OF STAPHYLOCOCCUS-AUREUS AND ARE INDUCED BY CADMIUM", Journal of bacteriology, 176(10), 1994, pp. 3040-3048

Abstract

pLm74 is the smallest known plasmid in Listeria monocytogenes. It confers resistance to the toxic divalent cation cadmium. It contains a 3.1-kb EcoRI fragment which hybridizes with the cadAC genes of plasmid pI258 of Staphylococcus aureus. When introduced into cadmium-sensitive L. monocytogenes or Bacillus subtilis strains, this fragment conferredcadmium resistance. The DNA sequence of the 3.1-kb EcoRI fragment contains two open reading frames, cadA and cadC. The deduced amino acid sequences are similar to those of the cad operon of plasmid pL258 of S.aureus, known to prevent accumulation of Cd2+ in the bacteria by an ATPase efflux mechanism. The cadmium resistance determinant of L. monocytogenes does not confer zinc resistance, in contrast to the cadAC determinant of S. aureus, suggesting that the two resistance mechanisms are slightly different. Slot blot DNA-RNA hybridization analysis showedcadmium-inducible synthesis of L. monocytogenes cadAC RNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:57:41