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Titolo:
2D AND 3D HIGH-RESOLUTION GRADIENT-ECHO FUNCTIONAL IMAGING OF THE BRAIN - VENOUS CONTRIBUTIONS TO SIGNAL IN MOTOR CORTEX STUDIES
Autore:
HAACKE EM; HOPKINS A; LAI S; BUCKLEY P; FRIEDMAN L; MELTZER H; HEDERA P; FRIEDLAND R; KLEIN S; THOMPSON L; DETTERMAN D; TKACH J; LEWIN JS;
Indirizzi:
WASHINGTON UNIV,SCH MED,MALLINCKRODT INST RADIOL,510 S KINGSHIGHWAY BLVD ST LOUIS MO 63110 CASE WESTERN RESERVE UNIV,DEPT ANAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT PHYS CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT PSYCHIAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,ALZHEIMER CTR CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT PSYCHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT RADIOL CLEVELAND OH 44106 CLEVELAND CLIN EDUC FDN,DEPT RADIOL CLEVELAND OH 44106
Titolo Testata:
NMR in biomedicine
fascicolo: 1-2, volume: 7, anno: 1994,
pagine: 54 - 62
SICI:
0952-3480(1994)7:1-2<54:2A3HGF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MR CONTRAST AGENTS; CEREBRAL PERFUSION; SUSCEPTIBILITY; ACTIVATION; DIFFUSION; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Haacke et al., "2D AND 3D HIGH-RESOLUTION GRADIENT-ECHO FUNCTIONAL IMAGING OF THE BRAIN - VENOUS CONTRIBUTIONS TO SIGNAL IN MOTOR CORTEX STUDIES", NMR in biomedicine, 7(1-2), 1994, pp. 54-62

Abstract

Recent emphasis on high resolution gradient echo studies in functional imaging has led to the conclusion that there are likely three domains of response to the blood circulation in the brain when considering field inhomogeneity effects of the venous blood pre- and during activation. The first is a coherent effect due to large or macroscopic vessels on the order of the size of the voxel (ca 200-500 mu m in most studies). These can lead to very large signal changes (up to 100%). The second is at the venule level (ca 50-200 mu m) and is associated with smaller parenchymal changes (usually ca 10% or less). The third is at thecapillary level and is associated with much smaller signal changes at1.5 T and even up to 4 T. The actual signal changes depend on field strength and sequence design. In this paper, we present our experience in detecting the first two domains with 2D and 3D gradient echo imaging at 1.5 T. We find that high resolution enables visualization of the larger small veins in motor cortex studies and that, on occasion, it is possible to see the venule effects as well. We suggest a simple model to explain the large signal changes based on susceptibility changes and partial volume effects. Comparisons of the functional imaging datato this model and to MR angiographic studies are also shown as evidence of the venous sources of the susceptibility changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:10:56