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Titolo:
PORE-FORMING PSEUDOMONAS-AERUGINOSA CYTOTOXIN
Autore:
XIONG G; STRUCKMEIER M; LUTZ F;
Indirizzi:
UNIV GIESSEN,INST PHARMAKOL & TOXIKOL,FRANKFURTER STR 107 D-35392 GIESSEN GERMANY UNIV GIESSEN,INST PHARMAKOL & TOXIKOL,FRANKFURTER STR 107 D-35392 GIESSEN GERMANY
Titolo Testata:
Toxicology
fascicolo: 1-3, volume: 87, anno: 1994,
pagine: 69 - 83
SICI:
0300-483X(1994)87:1-3<69:PPC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASCITES TUMOR-CELLS; STAPHYLOCOCCAL ALPHA-TOXIN; INTEGRAL MEMBRANE-PROTEIN; SITE-DIRECTED MUTAGENESIS; CYTO-TOXIN; NUCLEOTIDE-SEQUENCE; AEROMONAS-HYDROPHILA; BACTERIAL EXOTOXINS; ENDOTHELIAL-CELLS; BINDING-PROTEIN;
Keywords:
PORE-FORMER; PSEUDOMONAS-AERUGINOSA; CYTOTOXIN; CYTOLYSINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
G. Xiong et al., "PORE-FORMING PSEUDOMONAS-AERUGINOSA CYTOTOXIN", Toxicology, 87(1-3), 1994, pp. 69-83

Abstract

Pseudomonas aeruginosa procytotoxin protein is processed C-terminallyduring bacterial autolysis to generate the active 29-kDa cytotoxin molecule. Binding to target cell membranes is dependent upon Cys23 and Cys215 and a domain flanked to Cys215. On rabbit erythrocytes, cytotoxin binds to a 28-kDa peptide of a glycoprotein, its N-terminus shows high homology to channel integral membrane protein CHIP28. At concentrations of more than 3 x 10(-9) M, cytotoxin increases plasma membrane permeability of most eucaryotic cells investigated. The role of cytotoxin in the formation of pores with a diameter of 2 nm on mammalian cellsis discussed. The cytotoxin effects are coordinated with other pseudomonal products and the resultant concept of pathogenesis is presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:02:32