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Titolo:
REGIONAL CHEMOTHERAPY (WITH MITOMYCIN-C) AND INTRAOPERATIVE HYPERTHERMIA FOR DIGESTIVE CANCERS WITH PERITONEAL CARCINOMATOSIS
Autore:
GILLY FN; CARRY PY; SAYAG AC; BRACHET A; PANTEIX G; SALLE B; BIENVENU J; BURGARD G; GUIBERT B; BANSSILLON V; BRAILLON G;
Indirizzi:
CTR HOSP LYON SUD,DEPT GEN & THORAC SURG F-69310 LYON FRANCE CTR HOSP LYON SUD,DEPT ANESTHESIA & INTENS CARE LYON FRANCE CTR HOSP LYON SUD,DEPT BIOCHEM & IMMUNOL,HYPERTHERMIA & ONCOL LAB MS44 LYON FRANCE
Titolo Testata:
Hepato-gastroenterology
fascicolo: 2, volume: 41, anno: 1994,
pagine: 124 - 129
SICI:
0172-6390(1994)41:2<124:RC(MAI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-CANCER; INTRAPERITONEAL CHEMOHYPERTHERMIA; PERFUSION; CELLS; RECURRENCE; THERAPY; SURGERY; DISSEMINATION; TOLERANCE; TUMOR;
Keywords:
PERITONEAL CARCINOMATOSIS; INTRAPERITONEAL CHEMOTHERAPY; HYPERTHERMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
F.N. Gilly et al., "REGIONAL CHEMOTHERAPY (WITH MITOMYCIN-C) AND INTRAOPERATIVE HYPERTHERMIA FOR DIGESTIVE CANCERS WITH PERITONEAL CARCINOMATOSIS", Hepato-gastroenterology, 41(2), 1994, pp. 124-129

Abstract

Intraperitoneal chemo-hyperthermia with mitomycin C was used to treat28 patients with far advanced digestive adenocarcinoma and histologically confirmed peritoneal carcinomatosis. Surgical resection of the primary tumor was possible in 17 cases. After closure of the abdominal wall, intraperitoneal chemo-hyperthermia was performed for 90 to 120 minutes under general anesthesia and 32 degrees C hypothermia, through 3intraperitoneal drains forming a closed circuit, using 10 mg/1 of mitomycin C in 6 liters of peritoneal dialysate heated to an inflow temperature of 46-49 degrees C. No mortality occurred, and there were 2 post-operative complications, with transitory biological side effects. In9 out of 10 patients with preoperative malignant ascites, the ascitescleared after treatment. One-year survival rate was 54.2 %. These encouraging preliminary results show that intraperitoneal chemohyperthermia with mitomycin C is a safe and reliable treatment for peritoneal carcinomatosis in far advanced digestive cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:01:23