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Titolo:
EFFECT OF MONOUNSATURATED FATTY-ACIDS UNDER FIXED P S AND N-6/N-3 RATIOS ON LIPID-METABOLISM IN RATS/
Autore:
LU YF; WU HL;
Indirizzi:
FU JEN CATHOLIC UNIV,DEPT NUTR & FOOD SCI TAIPEI 242 TAIWAN
Titolo Testata:
Journal of nutritional science and vitaminology
fascicolo: 2, volume: 40, anno: 1994,
pagine: 189 - 200
SICI:
0301-4800(1994)40:2<189:EOMFUF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FECAL STEROID-EXCRETION; CORONARY HEART-DISEASE; HIGH-CHOLESTEROL DIET; PLASMA-CHOLESTEROL; LIPOPROTEIN METABOLISM; EICOSANOID PRODUCTION; LIVER CHOLESTEROL; UNSATURATED FATS; LATER RESPONSE; SATURATED FAT;
Keywords:
MONOUNSATURATED FATTY ACID; CHOLESTEROL; FECAL STEROIDS; LIPOPROTEIN; SERUM AND LIVER LIPIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
Y.F. Lu e H.L. Wu, "EFFECT OF MONOUNSATURATED FATTY-ACIDS UNDER FIXED P S AND N-6/N-3 RATIOS ON LIPID-METABOLISM IN RATS/", Journal of nutritional science and vitaminology, 40(2), 1994, pp. 189-200

Abstract

The purpose of the present study was to investigate the effect of monounsaturated fatty acid (MUFA), in particular oleic acid, under fixed P/S and n-6/n-3 ratios on serum and liver lipid metabolism in rats. The male Sprague-Dawley rats aged 28 days were fed diets low in MUFA (LM) or high in MUFA (HM) with or without 1% cholesterol for 4 weeks. Theexperimental diets contained 10% (w/w) fat. The body weight gain, food efficiency, and liver weight were comparable among the groups exceptfor an increase in liver weight by dietary cholesterol. When cholesterol-added diets were fed, the concentration of serum cholesterol in the HM group was higher than that of the corresponding LM group at second week and at the end of experiment. The concentration of serum triacylglycerol in rats fed a cholesterol-enriched HM diet was markedly lower than that of cholesterol-free counterpart. Both MUFA and cholesteroltended to increase serum low density lipoprotein-cholesterol concentration, but they had no interaction. Serum high density lipoprotein-cholesterol in cholesterol-enriched groups was lower than that in the cholesterol-free counterparts, but it was independent of the MUFA content. Dietary cholesterol markedly increased the concentration of liver cholesterol and triacylglycerol and the increase in liver cholesterol was more marked in the HM group than in the LM group, while the level ofliver triacylglycerol was comparable. The fecal excretion of neutral and acidic steroids increased when 1% cholesterol was added to the diets, irrespective of the MUFA content in the diets. Thus, the results indicate that the proposed beneficial effect of MUFA on cholesterol canbe modified when diet contains cholesterol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:53:43