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Titolo:
PROPOFOL INHIBITS PHAGOCYTOSIS AND KILLING OF STAPHYLOCOCCUS-AUREUS AND ESCHERICHIA-COLI BY POLYMORPHONUCLEAR LEUKOCYTES IN-VITRO
Autore:
KRUMHOLZ W; ENDRASS J; HEMPELMANN G;
Indirizzi:
UNIV GIESSEN,DEPT ANAESTHESIOL & INTENS CARE MED,KLIN STR 29 D-35392 GIESSEN GERMANY
Titolo Testata:
Canadian journal of anaesthesia
fascicolo: 5, volume: 41, anno: 1994,
parte:, 1
pagine: 446 - 449
SICI:
0832-610X(1994)41:5<446:PIPAKO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHILS; INVITRO;
Keywords:
ANESTHETICS, INTRAVENOUS, PROPOFOL; BLOOD, LEUKOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
W. Krumholz et al., "PROPOFOL INHIBITS PHAGOCYTOSIS AND KILLING OF STAPHYLOCOCCUS-AUREUS AND ESCHERICHIA-COLI BY POLYMORPHONUCLEAR LEUKOCYTES IN-VITRO", Canadian journal of anaesthesia, 41(5), 1994, pp. 446-449

Abstract

Polymorphonuclear leukocytes (PMNL) are important components of the immunological defence system which protects the human organism from invading bacteria. Using a fluorescence microscopic method, we examined the influence of propofol and its solvent intralipid on phagocytosis and killing of Staphylococcus aureus and Escherichia coli by PMNL in vitro. Propofol inhibited (P less than or equal to 0.001) phagocytosis ofStaphylococcus aureus as well as Escherichia coli. Killing of Staphylococcus aureus (P less than or equal to 0.001) and of Escherichia coli(P less than or equal to 0.01) war; suppressed Intralipid, by itself impaired phagocytosis of Escherichia coli (P less than or equal to 0.05). Apart from that, intralipid produced no relevant effects. Additional clinical studies regarding the influence of propofol on PMNL function are recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:23:40