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Titolo:
HALOTHANE BLOCKS SYNAPTIC EXCITATION OF INHIBITORY INTERNEURONS
Autore:
PEROUANSKY M; KIRSON ED; YAARI Y;
Indirizzi:
HEBREW UNIV JERUSALEM,HADASSAH UNIV HOSP,DEPT ANESTHESIA & CRIT CARE,POB 12000 IL-91010 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,SCH MED,DEPT PHYSIOL IL-91010 JERUSALEM ISRAEL
Titolo Testata:
Anesthesiology
fascicolo: 6, volume: 85, anno: 1996,
pagine: 1431 - 1438
SICI:
0003-3022(1996)85:6<1431:HBSEOI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL-NEURONS; CA1 PYRAMIDAL CELLS; VOLATILE ANESTHETICS; POSTSYNAPTIC CURRENTS; SPINAL-CORD; GENERAL-ANESTHETICS; ACTIVATED CHANNELS; RESPONSES; TRANSMISSION; MECHANISMS;
Keywords:
ANESTHETICS, VOLATILE, HALOTHANE; ANIMALS, MOUSE; BRAIN, HIPPOCAMPUS; CENTRAL NERVOUS SYSTEM EXCITATORY POSTSYNAPTIC CURRENTS; CENTRAL NERVOUS SYSTEM, RECEPTORS, GLUTAMATE, N-METHYL-D-ASPARTATE, NON-N-METHYL-D-ASPARTATE; CENTRAL NERVOUS SYSTEM, NEURON, INTERNEURON, PYRAMIDAL CELL; MEASUREMENT TECHNIQUE, HIPPOCAMPAL SLICE, PATCH-CLAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M. Perouansky et al., "HALOTHANE BLOCKS SYNAPTIC EXCITATION OF INHIBITORY INTERNEURONS", Anesthesiology, 85(6), 1996, pp. 1431-1438

Abstract

Background: Activation of principal hippocampal neurons is controlledby feedforward and feedback inhibition mediated by gamma-aminobutyricacidergic interneurons. The effects of halothane on glutamate receptor-mediated synaptic excitation of inhibitory interneurons have not been reported yet. Methods: The effects of halothane on glutamatergic excitatory postsynaptic currents and on spike threshold in visually identified interneurons were studied with tight-seal, whole-cell voltage- and current-clamp recordings in thin slices from adult mouse hippocampus, The excitatory postsynaptic currents were pharmacologically isolated into their N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated components using selective antagonists. Results: Halothane (0.37-2.78 mM) reversibly blocked non-N-methyl-D-aspartate and N-methyl-D-aspartate excitatory postsynaptic currents in hippocampal oriens-alveus interneurons. Half-maximal inhibition was observed at similar concentrations (0.59 mM and 0.50 mM, respectively). Halothane inhibited synaptically generated action potentials at concentrations that did not elevate the spike threshold. Conclusions: Halothane blocks glutamatereceptor-mediated synaptic activation of inhibitory interneurons in the mouse hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:09:21