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Titolo:
SYNTHESIS AND ANGIOTENSIN-CONVERTING ENZYME-INHIBITORY ACTIVITY OF N-[(1S)-1-CARBOXY-5-(4-PIPERIDYL)PENTYL]-L-ALANINE DERIVATIVES
Autore:
KORI M; ITOH K; INADA Y; KATOH T; SUMINO Y; NISHIKAWA K; SUGIHARA H;
Indirizzi:
TAKEDA CHEM IND LTD,PHARMACEUT RES LABS,2-17-85 JUSOHONMACHI,YODOGAWAKU OSAKA 532 JAPAN TAKEDA CHEM IND LTD,TECHNOL DEV LABS OSAKA 532 JAPAN TAKEDA CHEM IND LTD,PROD RES LABS,YODOGAWA KU OSAKA 532 JAPAN
Titolo Testata:
Chemical and Pharmaceutical Bulletin
fascicolo: 3, volume: 42, anno: 1994,
pagine: 580 - 585
SICI:
0009-2363(1994)42:3<580:SAAEAO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
1,5-BENZOXAZEPINE DERIVATIVES; STEREOSPECIFIC REDUCTION; 2-KETOCARBOXYLIC ACIDS; AMINO-ACIDS; 1,5-BENZOTHIAZEPINE; DESIGN; DEHYDROGENASE;
Keywords:
ACE INHIBITOR; N-[(1S)-1-CARBOXY-5-(4-PIPERIDYL)PENTYL]-L-ALANINE; STEREOSELECTIVE SYNTHESIS; ACTIVITY DURATION; ASYMMETRIC REDUCTION; LACTOBACILLUS-PARACASEI SUBSP PARACASEI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Kori et al., "SYNTHESIS AND ANGIOTENSIN-CONVERTING ENZYME-INHIBITORY ACTIVITY OF N-[(1S)-1-CARBOXY-5-(4-PIPERIDYL)PENTYL]-L-ALANINE DERIVATIVES", Chemical and Pharmaceutical Bulletin, 42(3), 1994, pp. 580-585

Abstract

As part of a search for potent and long-lasting angiotensin converting enzyme (ACE) inhibitors, various types of N-[(1S)-1-carboxy-5-(4-piperidyl)pentyl]-L-alanine derivatives (7a, 8-11) were prepared. The keysynthetic intermediate, nyl-4-piperidyl)-1-ethoxycarbonylpentyl]-L-alanine (17a), was synthesized by asymmetric reduction of the alpha-oxoester (13) with Lactobacillus paracasei subsp. paracasei followed by a substitution reaction with tert-butyl L-alaninate (15) and subsequent treatment with hydrogen chloride. Compounds 7a and 8-11 showed potent and long-lasting ACE-inhibitory activity in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:29:21