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Titolo:
DIFFERENT ALTERATIONS IN THE INSULIN-STIMULATED GLUCOSE-UPTAKE IN THEATHLETES HEART AND SKELETAL-MUSCLE
Autore:
NUUTILA P; KNUUTI MJ; HEINONEN OJ; RUOTSALAINEN U; TERAS M; BERGMAN J; SOLIN O; YKIJARVINEN H; VOIPIOPULKKI LM; WEGELIUS U; KOIVISTO VA;
Indirizzi:
UNIV TURKU,DEPT MED SF-20520 TURKU FINLAND UNIV TURKU,DEPT CLIN CHEM SF-20520 TURKU FINLAND UNIV TURKU,CTR CYCLOTRON PET SF-20520 TURKU FINLAND ABO AKAD UNIV,ACCELERATOR LAB SF-20520 TURKU FINLAND UNIV HELSINKI,DEPT MED 2 SF-00290 HELSINKI FINLAND
Titolo Testata:
The Journal of clinical investigation
fascicolo: 5, volume: 93, anno: 1994,
pagine: 2267 - 2274
SICI:
0021-9738(1994)93:5<2267:DAITIG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID METABOLISM; TRANSMURAL DISTRIBUTION; MYOCARDIAL-METABOLISM; HYPERTENSIVE RATS; PHYSICAL EXERCISE; HUMANS; INVIVO; TOMOGRAPHY; ECHOCARDIOGRAPHY; DEOXYGLUCOSE;
Keywords:
ENDURANCE TRAINING; HEART; SKELETAL MUSCLE; GLUCOSE UPTAKE; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
P. Nuutila et al., "DIFFERENT ALTERATIONS IN THE INSULIN-STIMULATED GLUCOSE-UPTAKE IN THEATHLETES HEART AND SKELETAL-MUSCLE", The Journal of clinical investigation, 93(5), 1994, pp. 2267-2274

Abstract

Physical training increases skeletal muscle insulin sensitivity. Since training also causes functional and structural changes in the myocardium, we compared glucose uptake rates in the heart and skeletal muscles of trained and untrained individuals. Seven male endurance athletes(VO(2)max 72+/-2 ml/kg/min) and seven sedentary subjects matched for characteristics other than VO(2)max (43 +/- 2 ml/kg/min) were studied. Whole body glucose uptake was determined with a 2-h euglycemic hyperinsulinemic clamp, and regional glucose uptake in femoral and arm muscles, and myocardium using F-18-fluoro-2-deoxy-D-glucose and positron emission tomography. Glucose uptake in the athletes was increased by 68%in whole body (P < 0.0001), by 99% in the femoral muscles (P < 0.01),and by 62% in arm muscles (P = 0.06), but it was decreased by 33% in the heart muscle (P < 0.05) as compared with the sedentary subjects. The total glucose uptake rate in the heart was similar in the athletes and control subjects. Left ventricular mass in the athletes was 79% greater (P < 0.001) and the meridional wall stress smaller (P < 0.001) as estimated by echocardiography. VO(2)max correlated directly with left ventricular mass (r = 0.87, P < 0.001) and inversely with left ventricular wall stress (r = -0.86, P < 0.001). Myocardial glucose uptake correlated directly with the rate-pressure product (r = 0.75, P < 0.02)and inversely with left ventricular mass (r = -0.60, P < 0.05) or with the whole body glucose disposal (r = -0.68, P < 0.01). Thus, in athletes, (a) insulin-stimulated glucose uptake is enhanced in the whole body and skeletal muscles, (b) whereas myocardial glucose uptake per muscle mass is reduced possibly due to decreased wall stress and energy requirements or the use of alternative fuels, or both.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:01:15