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Titolo:
COMPARISON OF DIFFERENT TECHNIQUES OF HYPOTHERMIC PIG-HEART PRESERVATION
Autore:
FERRERA R; LARESE A; MARCSEK P; GUIDOLLET J; VERDYS M; DITTMAR A; DUREAU G;
Indirizzi:
INSERM,U63,22 AVE DOYEN LEPINE,CASE 18 F-69675 BRON FRANCE INSERM,U63 F-69008 LYON FRANCE CTR TRANSFUS SANGUINE,CRYOBIOL LAB LYON FRANCE
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 5, volume: 57, anno: 1994,
pagine: 1233 - 1239
SICI:
0003-4975(1994)57:5<1233:CODTOH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-FLOW PERFUSION; ORTHOTOPIC TRANSPLANTATION; MYOCARDIAL PRESERVATION; COLD-STORAGE; RAT-HEART; CARDIOPLEGIA; REDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R. Ferrera et al., "COMPARISON OF DIFFERENT TECHNIQUES OF HYPOTHERMIC PIG-HEART PRESERVATION", The Annals of thoracic surgery, 57(5), 1994, pp. 1233-1239

Abstract

The aim of this study was to compare several methods of hypothermic heart preservation. Isolated pig hearts were preserved for 24 hours in cold cardioplegic solution (St. Thomas' Hospital modified solution) bycontinuous perfusion (group I), microperfusion (group II), or simple storage (group III). The findings were then compared with those from hearts harvested and immediately reperfused (the control group). Group III hearts showed lower adenosine triphosphate preservation (0.47 +/- 0.18 mu mol/g) than did group I and II hearts and the control hearts (1.86 +/- 0.40, 1.98 +/- 0.27, and 1.84 +/- 0.55 mu mol/g, respectively). Electronic microscopy studies also revealed that the myocardial cells in the group III hearts appeared to be damaged. After the hearts had undergone preservation, myocardial function was studied for 60 minutes under nonworking conditions using an ex vivo functional testing system. For group III, the mean left ventricular developed pressure and ventricular compliance (16 +/- 22 and 63 +/- 48 mm Hg, respectively) differed significantly from those for group I (83 +/- 26 and 0 +/- 0 mm Hg, respectively), group II (83 +/- 33 and 14 +/- 18 mm Hg, respectively), and the control group (115 +/- 13 and 0 +/- 0 mm Hg, respectively). We concluded from our findings that perfusion methods are superior to cold storage but inadequate to maintain heart viability for the long term during hypothermia. These techniques must be improved before they can be adopted for clinical use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:24:05