Catalogo Articoli (Spogli Riviste)
OPAC HELP
Titolo: T-CELL SUBSET DISTRIBUTION AND B-CELL HYPERREACTIVITY IN MICE EXPRESSING INTERLEUKIN-4 UNDER THE CONTROL OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I REGULATORY SEQUENCES
Autore: ERB KJ; HOLTSCHKE T; MUTH K; HORAK I; SCHIMPL A;
- Indirizzi:
- UNIV WURZBURG,INST VIROL & IMMUNBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY UNIV WURZBURG,INST VIROL & IMMUNBIOL D-97078 WURZBURG GERMANY
- Titolo Testata:
- European Journal of Immunology
fascicolo: 5,
volume: 24,
anno: 1994,
pagine: 1143 - 1147
- SICI:
- 0014-2980(1994)24:5<1143:TSDABH>2.0.ZU;2-6
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- STIMULATORY FACTOR-I; TRANSGENIC MICE; THYMOCYTE DEVELOPMENT; MONOCLONAL-ANTIBODY; DEFICIENT MICE; IL-4; PROLIFERATION; IGE; DIFFERENTIATION; ACTIVATION;
- Keywords:
- INTERLEUKIN-4 TRANSGENIC MICE; THYMUS; T CELL SUBPOPULATION; B CELL HYPERREACTIVITY;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 35
- Recensione:
- Indirizzi per estratti:
-
-
-
- Citazione:
- K.J. Erb et al., "T-CELL SUBSET DISTRIBUTION AND B-CELL HYPERREACTIVITY IN MICE EXPRESSING INTERLEUKIN-4 UNDER THE CONTROL OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I REGULATORY SEQUENCES", European Journal of Immunology, 24(5), 1994, pp. 1143-1147
Abstract
Transgenic mice in which interleukin-4 (IL-4) is expressed under the control of the major histocompatibility complex (MHC) class I regulatory sequences show low level expression of IL-4 in all organs investigated. Several weeks after birth the animals develop thymus hypoplasia with a loss of CD4(+)CD8(+) double-positive cells and a relative increase in the mature population, especially, and in contrast to previouslypublished lines, the CD4(+) single-positive cells. In the periphery, T lymphocytes eventually decline, CD8(+) cells being more strongly affected. Many of the residual T cells exhibit the CD44(high)Mel-14(low) phenotype of antigenically experienced T cells. B cells also show an activated phenotype with respect to size, MHC class II and CD23 expression, are more readily stimulated by anti-mu F(ab')(2) antibodfies thanare B cells from control littermates, and show a higher sontaneous and antigen-induced production of IgG1 and IgE.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:48:21