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Titolo:
T-CELL SUBSET DISTRIBUTION AND B-CELL HYPERREACTIVITY IN MICE EXPRESSING INTERLEUKIN-4 UNDER THE CONTROL OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I REGULATORY SEQUENCES
Autore:
ERB KJ; HOLTSCHKE T; MUTH K; HORAK I; SCHIMPL A;
Indirizzi:
UNIV WURZBURG,INST VIROL & IMMUNBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY UNIV WURZBURG,INST VIROL & IMMUNBIOL D-97078 WURZBURG GERMANY
Titolo Testata:
European Journal of Immunology
fascicolo: 5, volume: 24, anno: 1994,
pagine: 1143 - 1147
SICI:
0014-2980(1994)24:5<1143:TSDABH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATORY FACTOR-I; TRANSGENIC MICE; THYMOCYTE DEVELOPMENT; MONOCLONAL-ANTIBODY; DEFICIENT MICE; IL-4; PROLIFERATION; IGE; DIFFERENTIATION; ACTIVATION;
Keywords:
INTERLEUKIN-4 TRANSGENIC MICE; THYMUS; T CELL SUBPOPULATION; B CELL HYPERREACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
K.J. Erb et al., "T-CELL SUBSET DISTRIBUTION AND B-CELL HYPERREACTIVITY IN MICE EXPRESSING INTERLEUKIN-4 UNDER THE CONTROL OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I REGULATORY SEQUENCES", European Journal of Immunology, 24(5), 1994, pp. 1143-1147

Abstract

Transgenic mice in which interleukin-4 (IL-4) is expressed under the control of the major histocompatibility complex (MHC) class I regulatory sequences show low level expression of IL-4 in all organs investigated. Several weeks after birth the animals develop thymus hypoplasia with a loss of CD4(+)CD8(+) double-positive cells and a relative increase in the mature population, especially, and in contrast to previouslypublished lines, the CD4(+) single-positive cells. In the periphery, T lymphocytes eventually decline, CD8(+) cells being more strongly affected. Many of the residual T cells exhibit the CD44(high)Mel-14(low) phenotype of antigenically experienced T cells. B cells also show an activated phenotype with respect to size, MHC class II and CD23 expression, are more readily stimulated by anti-mu F(ab')(2) antibodfies thanare B cells from control littermates, and show a higher sontaneous and antigen-induced production of IgG1 and IgE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:48:21