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Titolo:
IDENTIFICATION OF AN INVASION-INDUCING GENE, TIAM-1, THAT ENCODES A PROTEIN WITH HOMOLOGY TO GDP-GTP EXCHANGERS FOR RHO-LIKE PROTEINS
Autore:
HABETS GGM; SCHOLTES EHM; ZUYDGEEST D; VANDERKAMMEN RA; STAM JC; BERNS A; COLLARD JG;
Indirizzi:
ANTONI VAN LEEUWENHOEK HUIS,NETHERLANDS CANC INST,DIV CELL BIOL,121 PLESMANLAAN 1066 CX AMSTERDAM NETHERLANDS ANTONI VAN LEEUWENHOEK HUIS,NETHERLANDS CANC INST,DIV MOLEC GENET 1066 CX AMSTERDAM NETHERLANDS
Titolo Testata:
Cell
fascicolo: 4, volume: 77, anno: 1994,
pagine: 537 - 549
SICI:
0092-8674(1994)77:4<537:IOAIGT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUANINE-NUCLEOTIDE EXCHANGE; MURINE LEUKEMIA-VIRUS; T-LYMPHOMA CELLS; BINDING-PROTEIN; HEMATOPOIETIC-CELLS; ACTIVATING PROTEIN; SIGNALING PROTEINS; CDC42HS PROTEIN; HUMAN ONCOGENE; BCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
G.G.M. Habets et al., "IDENTIFICATION OF AN INVASION-INDUCING GENE, TIAM-1, THAT ENCODES A PROTEIN WITH HOMOLOGY TO GDP-GTP EXCHANGERS FOR RHO-LIKE PROTEINS", Cell, 77(4), 1994, pp. 537-549

Abstract

Using proviral tagging in combination with in vitro selection for invasiveness, we have identified a gene, designated Tiam-1, that affects invasion. In the selected invasive T lymphoma variants, proviral insertions were found within coding exons of the Tiam-1 gene, resulting in both truncated 5'-end and 3'-end transcripts that give rise to N- and C-terminal Tiam-1 protein fragments. In one invasive variant, amplification of the Tiam-1 locus was observed with concomitant increase in the amount of normal Tiam-1 protein. Cell clones that were invasive in vitro produced experimental metastases in nude mice, and transfection of truncated Tiam-1 cDNAs into noninvasive cells made these cells invasive. The predicted Tiam-1 protein harbors a Dbl- and Pleckstrin-homologous domain, which it shares with GDP-GTP exchangers for Rho-like proteins that have been implicated in cytoskeletal organization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 18:09:38