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Titolo:
HECA-452(-CELLS MIGRATE THROUGH SUPERFICIAL VASCULAR PLEXUS BUT NOT THROUGH DEEP VASCULAR PLEXUS ENDOTHELIUM() T)
Autore:
KUNSTFELD R; LECHLEITNER S; GROGER M; WOLFF K; PETZELBAUER P;
Indirizzi:
UNIV VIENNA,SCH MED,DEPT DERMATOL,WAEHRINGER GUERTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,SCH MED,DEPT DERMATOL A-1090 VIENNA AUSTRIA
Titolo Testata:
Journal of investigative dermatology
fascicolo: 3, volume: 108, anno: 1997,
pagine: 343 - 348
SICI:
0022-202X(1997)108:3<343:HMTSVP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIN-DEFICIENT MICE; LYMPHOCYTE-ASSOCIATED ANTIGEN; HOMING RECEPTOR; ADHESION MOLECULE-1; EXPRESSION; RECIRCULATION; RECRUITMENT; EPITOPE; DISEASE; SITES;
Keywords:
SCID MOUSE; XENOGRAFT; ELAM-1; INTERLEUKIN-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Kunstfeld et al., "HECA-452(-CELLS MIGRATE THROUGH SUPERFICIAL VASCULAR PLEXUS BUT NOT THROUGH DEEP VASCULAR PLEXUS ENDOTHELIUM() T)", Journal of investigative dermatology, 108(3), 1997, pp. 343-348

Abstract

The skin is nourished by two interconnected vascular systems, the superficial vascular plexus coursing just beneath the epidermis and the deep vascular plexus located above the subcutaneous tissue. Skin inflammatory T cells in diseases, such as psoriasis or dermatitis, strikingly aim for the superficial vascular plexus without involving the deep vascular plexus, and the infiltrating T cells bear a distinct phenotypeexpressing the cutaneous lymphocyte-associated antigen, which is recognized by mAb HECA-452, We wanted to know whether HECA-452(+) lymphocytes indeed are able to distinguish between superficial and deep vascular plexus homing sites, Employing the hu-SCID mouse model grafted withhuman skin and human T cells, as described previously, we developed anew skin-grafting strategy providing superficial and deep vascular plexus skin specimens placed separately onto the same mouse. Fourteen days after allogeneic human T cell grafting, both human skin sites were densely infiltrated by human T cells, but only T cells within the superficial vascular plexus, but not within the deep vascular plexus, expressed the cutaneous lymphocyte-associated antigen. IL-2 and IFN-gamma expression and allogeneic vessel destruction were present within both superficial and deep vascular plexus skin, This model provides direct evidence that expression of a specific homing receptor is indeed able to direct lymphocyte traffic, not only to a distinct organ but also toa distinct vascular bed within one organ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:55:24