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Titolo:
INTRASPLENIC IMMUNIZATION WITH INFECTED HEPATOCYTES - A MOUSE MODEL FOR STUDYING PROTECTIVE IMMUNITY AGAINST MALARIA PREERYTHROCYTIC STAGE
Autore:
RENIA L; RODRIGUES MM; NUSSENZWEIG V;
Indirizzi:
CHU PITIE SALPETRIERE,INSERM,U313,91 BLD HOP F-75013 PARIS FRANCE NYU,SCH MED,DEPT PATHOL,MICHAEL HEIDELBERGER DIV IMMUNOL NEW YORK NY 00000 NYU,SCH MED,DEPT MED & MOLEC PARASITOL NEW YORK NY 00000
Titolo Testata:
Immunology
fascicolo: 1, volume: 82, anno: 1994,
pagine: 164 - 168
SICI:
0019-2805(1994)82:1<164:IIWIH->2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-BERGHEI SPOROZOITES; KUPFFER CELLS; TRANSPLANTATION; VACCINATION; INVITRO; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
L. Renia et al., "INTRASPLENIC IMMUNIZATION WITH INFECTED HEPATOCYTES - A MOUSE MODEL FOR STUDYING PROTECTIVE IMMUNITY AGAINST MALARIA PREERYTHROCYTIC STAGE", Immunology, 82(1), 1994, pp. 164-168

Abstract

Malaria liver forms are the target of antibody or T-cell-mediated immune mechanisms induced by previous or subsequent developmental stages of the parasite. The potential for vaccine development of antigens expressed exclusively in the liver stages has not been fully explored partly because of the lack of an experimental animal model. Here we show that protective immunity against sporozoite-induced infection with Plasmodium yoelii and P. berghei can be obtained by intrasplenic injection of a small number of liver stages of the parasites. The serum of theprotected animals did not contain antibodies against sporozoites, liver or blood stage malaria parasites. Protective immunity was abolishedby depletion of either CD4(+) or CD8(+) T cells from the vaccinated mice before challenge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 09:28:24