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Titolo:
GENETIC-ANALYSIS INDICATES THAT THE HUMAN FOAMY VIRUS BEL-1 PROTEIN CONTAINS A TRANSCRIPTION ACTIVATION DOMAIN OF THE ACIDIC CLASS
Autore:
BLAIR WS; BOGERD H; CULLEN BR;
Indirizzi:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,BOX 3025 DURHAM NC 27710 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST DURHAM NC 27710 DUKE UNIV,SCH MED,GENET SECT DURHAM NC 27710
Titolo Testata:
Journal of virology
fascicolo: 6, volume: 68, anno: 1994,
pagine: 3803 - 3808
SICI:
0022-538X(1994)68:6<3803:GITTHF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING; MAMMALIAN-CELLS; EXPRESSION; VECTORS; REGION; SITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
W.S. Blair et al., "GENETIC-ANALYSIS INDICATES THAT THE HUMAN FOAMY VIRUS BEL-1 PROTEIN CONTAINS A TRANSCRIPTION ACTIVATION DOMAIN OF THE ACIDIC CLASS", Journal of virology, 68(6), 1994, pp. 3803-3808

Abstract

Human foamy virus encodes a nuclear regulatory protein, termed Bel-1,that serves as a potent activator of viral transcription. Mutational analysis has identified a small, discrete activation domain within Bel-1 that is highly active in both higher and lower eukaryotic cells. Here, we demonstrate that the activation domain of Bel-1 is highly dependent on the ADA2 transcriptional adaptor for biological activity in yeast cells, a property previously shown to be a hallmark of the VP16 class of acidic transcriptional activators (S. L. Berger, B. Pina, N. Silverman, G. A. Marcus, J. Agapite, J. L. Regier, S. J. Triezenberg, and L. Guarente, Cell 70:251-265, 1992). Using genetic selection in yeast cells, we have derived a set of point mutants within the Bel-1 activation domain that display a qualitatively similar loss in activation potential when examined in either yeast or human cells. These data indicate that the Bel-1 activation domain functions similarly in both lower and higher eukaryotes and strongly suggest that Bel-1 belongs to theVP16 class of acidic transcription factors.

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Documento generato il 25/11/20 alle ore 14:06:42