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Titolo:
MECHANISMS MEDIATING THE EFFECTS OF CHOLECYSTOKININ ON AVIAN SMALL-INTESTINE LONGITUDINAL SMOOTH-MUSCLE
Autore:
MARTIN MT; FERNANDEZ E; GONALONS E; FERNANDEZ AG;
Indirizzi:
UNIV AUTONOMA BARCELONA,DEPT PHYSIOL & CELL BIOL E-08193 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,DEPT PHYSIOL & CELL BIOL E-08193 BARCELONA SPAIN
Titolo Testata:
Regulatory peptides
fascicolo: 2, volume: 51, anno: 1994,
pagine: 91 - 99
SICI:
0167-0115(1994)51:2<91:MMTEOC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON EVOLUTIONARY ORIGIN; GUINEA-PIG ILEUM; SUBSTANCE-P; GASTRIN RECEPTOR; CHICKEN ANTRUM; AMINO-ACID; CCK-A; OCTAPEPTIDE; PEPTIDE; ANTAGONISTS;
Keywords:
CHICKEN; BIRD; GASTROINTESTINAL MOTILITY; SUBSTANCE P; L365,260; L364,718;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Martin et al., "MECHANISMS MEDIATING THE EFFECTS OF CHOLECYSTOKININ ON AVIAN SMALL-INTESTINE LONGITUDINAL SMOOTH-MUSCLE", Regulatory peptides, 51(2), 1994, pp. 91-99

Abstract

The aims of this study were (1) to define the effects of CCK-8s and related peptides on chicken ileum longitudinal smooth muscle and (2) toexplore the mechanisms by which such effects occur. The effects of CCK-8s were assayed in vitro on chicken longitudinal ileal strips. CCK-8s produced contraction of ileal strips (EC50 8.8.10(-9) M). CCK-8ns and CCK-4 did not have remarkable contractile effects even when added atconcentrations 200-times higher than the EC50 for CCK-8s. L365,260 slightly inhibited the effects of CCK-8s whereas L364,718 was ineffective. Tetrodotoxin (10(-6) M) markedly decreased the effects of CCK-8s. Atropine(10(-6) M) did not modify the neurally mediated effects of CCK-8s, whereas ketanserin (10(-5) M) decreased the response to CCK-8s. Substance P-desensitized preparations exhibited reduced responses to CCK-8s. Our results indicate that CCK receptors present in chicken ileum behave similarly but not identically to the CCK-A receptor described in mammals. Most of these CCK receptors are neurally located but a minor proportion is also present on smooth muscle. The neurally mediated response to CCK-8s does not involve cholinergic mechanisms, but serotonin and substance P releasing neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:05:10