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Titolo:
PHARMACOKINETICS AND PHARMACODYNAMICS OF SLOW-RELEASE TABLET OF DILTIAZEM IN HYPERTENSIVE PATIENTS WITH VARIOUS RENAL FUNCTIONS
Autore:
CHEN SX; GU TH; SONG DJ; GUO JZ; WANG XM; GONG LS;
Indirizzi:
SHANGHAI RES INST HYPERTENS SHANGHAI 200025 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 3, volume: 15, anno: 1994,
pagine: 263 - 266
SICI:
0253-9756(1994)15:3<263:PAPOST>2.0.ZU;2-A
Fonte:
ISI
Lingua:
CHI
Keywords:
DILTIAZEM; DELAYED-ACTION PREPARATIONS; PHARMACOKINETICS; BLOOD PRESSURE; KIDNEY FUNCTION TESTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
S.X. Chen et al., "PHARMACOKINETICS AND PHARMACODYNAMICS OF SLOW-RELEASE TABLET OF DILTIAZEM IN HYPERTENSIVE PATIENTS WITH VARIOUS RENAL FUNCTIONS", Zhongguo yaoli xuebao, 15(3), 1994, pp. 263-266

Abstract

Twenty hypertensive patients were equally divided into 2 groups: A) with normal renal function (NRF) and B) with impaired renal function (IRF) according to creatinine clearance, blood urea nitrogen and creatinine levels. The pharmacokinetic and pharmacodynamic effects of diltiazem (Dil, 90 mg, bid X 7 d, po) were studied. The pharmacokinetic parameters in IRF patients (K(a)0.7 +/-0.2 h-1, T1/2e3.7 +/- 0. 7 h, C(max)45 +/- 4 ng.ml-1, T(max1)3.1 +/- 0.4 h) did not differ from those in NRF patients (0.7 +/- 0.5 h-1, 4.1 +/- 1.3 h, 41 +/- 5 ng.ml-1 and 3.4+/- 0.4 h, P > 0.05). Antihypertensive efficacy of Dil in patients with IRF was similar to that in those with NRF, and the hypotensive effect lasted over 24 h. The plasma Dil concentrations were strongly correlated with a decrease in BP. in both groups. It was concluded that IRFdid not affect the disposition of slow release Dil tablet under a steady state. No dosage adjustment of Dil is necessary in hypertensive patients with IRF.

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Documento generato il 03/12/20 alle ore 21:48:35