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Titolo:
THE INDUCTION OF SEROTONIN(3)-LIKE RECEPTOR SUPERSENSITIVITY AND DOPAMINE-RECEPTOR SUBSENSITIVITY IN THE RAT MEDIAL PREFRONTAL CORTEX AFTERTHE INTRAVENTRICULAR ADMINISTRATION OF THE NEUROTOXIN 5,7-DIHYDROXYTRYPTAMINE - A MICROIONTOPHORETIC STUDY
Autore:
ASHBY CR; ZHANG JY; EDWARDS E; WANG RY;
Indirizzi:
SUNY STONY BROOK,DEPT PSYCHIAT & BEHAV SCI,PUTNAM HALL,S CAMPUS STONYBROOK NY 11794 SUNY STONY BROOK,DEPT PSYCHIAT & BEHAV SCI STONY BROOK NY 11794 BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11794 UNIV MARYLAND,DEPT PHARMACOL & TOXICOL BALTIMORE MD 21100
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 60, anno: 1994,
pagine: 453 - 462
SICI:
0306-4522(1994)60:2<453:TIOSRS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENERVATION SUPER-SENSITIVITY; ELECTROPHYSIOLOGICAL CHARACTERIZATION; SEROTONERGIC SYSTEM; RELEASE; NEURONS; SELECTIVITY; HIPPOCAMPUS; DERIVATIVES; ACTIVATION; HYDROLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Ashby et al., "THE INDUCTION OF SEROTONIN(3)-LIKE RECEPTOR SUPERSENSITIVITY AND DOPAMINE-RECEPTOR SUBSENSITIVITY IN THE RAT MEDIAL PREFRONTAL CORTEX AFTERTHE INTRAVENTRICULAR ADMINISTRATION OF THE NEUROTOXIN 5,7-DIHYDROXYTRYPTAMINE - A MICROIONTOPHORETIC STUDY", Neuroscience, 60(2), 1994, pp. 453-462

Abstract

This study examines the effect of intraventricular administration of the neurotoxin 5,7-dihydroxytryptamine on serotonin(1A), serotonin(2) and serotonin(3) receptors in the rat medial prefrontal cortex using in vivo extracellular single cell recording and iontophoresis. Iontophoresis of the serotonin(1A), serotonin(1C,2) and serotonin(3) receptor agonists (+/-)-8-hydroxy-(di-n-propyl)aminotetralin, +/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and 2-methylserotonin, respectively,produces a current-dependent (5-80 nA) suppression of the basal firing rate of medial prefrontal cortical cells in sham- and 5,7-dihydroxytryptamine-lesioned rats. The suppression produced by 2-methylserotoninand serotonin was significantly greater in 5,7-dihydroxytryptamine-lesioned rats than in control rats. No significant difference in the spontaneous activity of medial prefrontal cortex cells was observed between experimental and control rats after iontophoresis of (+/-)-8-hydroxy-(di-n-propyl)aminotetralin or +/-)-1(2,5-dimethoxy-4-iodophenyl)-2-aminopropane. There was no significant difference between the groups regarding the response of medial prefrontal cortex cells to the iontophoresis of GABA, whereas the response of medial prefrontal cortex cells to the iontophoresis of dopamine was significantly attenuated in animals pretreated with 5,7-dihydroxytryptamine compared to controls. Our results indicate that 5,7-dihydroxytryptamine-induced denervation selectively enhances the sensitivity of serotonin(3)-like receptors in the medial prefrontal cortex, which could, at least partially, account forthe serotonin denervation supersensitivity. Moreover, the finding that the response of medial prefrontal cortical cells to the iontophoresis of dopamine is attenuated in 5,7-dihydroxytrptamine pretreated rats is consistent with the view that the inhibitory action of dopamine in the medial prefrontal cortex is dependent upon serotonin tone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:38:18