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Titolo:
SELECTIVE AMYLIN ANTAGONIST SUPPRESSES RISE IN PLASMA LACTATE AFTER INTRAVENOUS GLUCOSE IN THE RAT - EVIDENCE FOR A METABOLIC ROLE OF ENDOGENOUS AMYLIN
Autore:
YOUNG AA; GEDULIN B; GAETA LSL; PRICKETT KS; BEAUMONT K; LARSON E; RINK TJ;
Indirizzi:
AMYLIN PHARMACEUT INC,9373 TOWNE CTR DR SAN DIEGO CA 92121
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 343, anno: 1994,
pagine: 237 - 241
SICI:
0014-5793(1994)343:3<237:SAASRI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET AMYLOID POLYPEPTIDE; GENE-RELATED PEPTIDE; ACTIVATES GLYCOGEN-PHOSPHORYLASE; SOLEUS MUSCLE; INSULIN; RESISTANCE; RESPONSES; INGESTION; PANCREAS; ARGININE;
Keywords:
INSULIN; POSTPRANDIAL; GLYCOGENOLYSIS; GLYCOLYSIS; AC187;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Young et al., "SELECTIVE AMYLIN ANTAGONIST SUPPRESSES RISE IN PLASMA LACTATE AFTER INTRAVENOUS GLUCOSE IN THE RAT - EVIDENCE FOR A METABOLIC ROLE OF ENDOGENOUS AMYLIN", FEBS letters, 343(3), 1994, pp. 237-241

Abstract

Data presented here provide the first demonstration that circulating amylin regulates metabolism in vivo, and support an endocrine hormonalrole that is distinct from its autocrine action at pancreatic islets. When rats were pre-treated with the potent amylin antagonist AC187 (n= 18), and then administered a 2 mmol glucose load, the rise in plasma lactate was less than in rats administered glucose only (n = 27; P <0.02). When rats were treated so that plasma glucose and insulin profiles were similar (n = 8), the increase in plasma lactate in the presence of AC187 was only 50.3% as high as the increase when AC187 was absent (P < 0.001). These experimental results fit with the View that some of the lactate appearing in plasma after a glucose load comes from insulin-sensitive tissues. The experiments also support the view that an important fraction of the increase in lactate depends on processes inhibited by a selective amylin antagonist, most likely amylin action in muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:41:28