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Titolo:
CHEMOTHERAPY OF HUMAN ALPHA-FETOPROTEIN-PRODUCING GASTRIC CARCINOMAS GROWN IN NUDE-MICE
Autore:
AIZAWA K; MOTOYAMA T; UEKI K; SUZUKI S; TANAKA N; YABUSAKI H; SUZUKI T; HATAKEYAMA K;
Indirizzi:
NIIGATA UNIV,SCH MED,DEPT SURG 1,1-757 ASAHIMACHI DORI NIIGATA 951 JAPAN YAMAGATA UNIV,SCH MED,DEPT PATHOL 2 YAMAGATA 99023 JAPAN
Titolo Testata:
Oncology Reports
fascicolo: 2, volume: 4, anno: 1997,
pagine: 397 - 400
SICI:
1021-335X(1997)4:2<397:COHAGC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER; DIFFERENTIATION; FEATURES; STOMACH;
Keywords:
GASTRIC CARCINOMA; ALPHA-FETOPROTEIN; HEPATOID ADENOCARCINOMA; EXPERIMENTAL CHEMOTHERAPY; LIVER METASTASIS; NUDE MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
K. Aizawa et al., "CHEMOTHERAPY OF HUMAN ALPHA-FETOPROTEIN-PRODUCING GASTRIC CARCINOMAS GROWN IN NUDE-MICE", Oncology Reports, 4(2), 1997, pp. 397-400

Abstract

We have examined the effects of chemotherapeutic drugs on tumor growth and metastasis of human alpha-fetoprotein-producing gastric carcinoma (AFPGC) xenografts growing in nude mice. These xenografts consisted of 3 hepatoid adenocarcinomas and 2 non-hepatoid, poorly differentiated adenocarcinomas. Mitomycin C and cisplatin inhibited the tumor growth and liver metastasis of hepatoid adenocarcinomas in nude mice. 5-fluorouracil also inhibited the growth of hepatoid adenocarcinomas but did not exhibit a significant antimetastatic action. Doxorubicin was effective only against non-hepatoid adenocarcinomas. These results indicate that chemotherapeutic drugs for AFPGC should be used according to the subtype of the tumor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 12:41:26