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Titolo:
COMPARISON OF THE BIOLOGICAL-ACTIVITY OF SYNTHETIC N-ACYLATED ASPARAGINE OR SERINE LINKED MONOSACCHARIDE LIPID A ANALOGS
Autore:
SHIMIZU T; IWAMOTO Y; YANAGIHARA Y; RYOYAMA K; SUHARA Y; IKEDA K; ACHIWA K;
Indirizzi:
SHIZUOKA UNIV,SCH PHARMACEUT SCI,DEPT MICROBIOL SHIZUOKA JAPAN SHIZUOKA UNIV,SCH PHARMACEUT SCI,DEPT MED CHEM SHIZUOKA JAPAN KANAZAWA UNIV,CANC RES INST,DEPT EXPT THERAPEUT KANAZAWA ISHIKAWA 920JAPAN
Titolo Testata:
Immunobiology
fascicolo: 4, volume: 196, anno: 1996,
pagine: 321 - 331
SICI:
0171-2985(1996)196:4<321:COTBOS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CHEMICALLY SYNTHESIZED ANALOGS; NONREDUCING SUGAR MOIETY; LPS BINDING-PROTEIN; ANTITUMOR-ACTIVITY; LIPOPOLYSACCHARIDE LPS; A ANALOGS; MICE; BACTERIAL; DERIVATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T. Shimizu et al., "COMPARISON OF THE BIOLOGICAL-ACTIVITY OF SYNTHETIC N-ACYLATED ASPARAGINE OR SERINE LINKED MONOSACCHARIDE LIPID A ANALOGS", Immunobiology, 196(4), 1996, pp. 321-331

Abstract

The mitogenicity, lethal toxicity, induction of tumor necrosis factor(TNF), production of nitric oxide (NO) and antitumor activity againstMeth A fibrosarcoma by chemically synthesized N-acylated asparagine-linked (A-701, A-702 and A-703) or N-acylated serine-linked (A-607) nonphosphorylated acylglucosamine and il 4-0-phosphorylated acylglucosamine (A-103) derived lipid A analogs were determined. Compound A-607 (with tetradecanoyl and (R)-3-tetradecanoyloxytetradecanoyl at the C-2 and C-3 positions) induced a significant incorporation of H-3-thymidine into splenocytes of C3H/He mice at concentrations ranging from 3.13 to50 mu M, but the mitogenic activity of A-701 (2-N-acetylglucosamine),A-702 (tetradecanoyl at the C-2), and A-703 (with (R)-tetradecanoyloxytetradecanoyl and tetradecanoyl at the C-2 and C-3) was very weak. The lethality of A-703 and A-103 (with (R)-3-tetradecanoyloxytetradecanoyl at the C-2 and C-3) was weaker than that of A-607 at doses of 300 and 750 nmol/kg in C57BL/b mice loaded with D-galactosamine. Peritonealmacrophages, stimulated with A-701-A-703, caused production of TNF which induce L929 cell lysis in vitro, and A-703 showed a high production of TNF The compounds, except for A-607, exhibited little NO production by macrophages, but did induce the NO production in the presence ofinterferon gamma. Induction of TNF and NO inducible activity by A-703was lower than that of A-607. A-703, A-607 and A-103 showed antitumoractivity against Meth A fibrosarcoma in BALB/c mice. When A-703 or A-103 with muramyl dipeptide was administered, A-703 failed to show combined effects, but A-103 did. We concluded from these findings that thebiological potency of asparagine compounds appears to be placed between serine- and amino-free compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 16:02:29