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Titolo:
COMBINED K- REPLETION CORRECTS AUGMENTED H+ SECRETION BY DISTAL TUBULES IN CHRONIC ALKALOSIS( AND CL)
Autore:
WESSON DE;
Indirizzi:
BAYLOR COLL MED,VET AFFAIRS MED CTR,RENAL SECT 111J,2002 HOLCOMBE BLVD HOUSTON TX 77030
Titolo Testata:
The American journal of physiology
fascicolo: 4, volume: 266, anno: 1994,
parte:, 2
pagine: 60000592 - 60000603
SICI:
0002-9513(1994)266:4<60000592:CKRCAH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BICARBONATE REABSORPTION; MEDULLARY COLLECTING DUCT; METABOLIC ALKALOSIS; RAT; ACIDIFICATION; CHLORIDE; NEPHRON; MODULATION; TRANSPORT; VOLUME;
Keywords:
BICARBONATE; ACIDIFICATION; REABSORPTION; MICROPUNCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Wesson, "COMBINED K- REPLETION CORRECTS AUGMENTED H+ SECRETION BY DISTAL TUBULES IN CHRONIC ALKALOSIS( AND CL)", The American journal of physiology, 266(4), 1994, pp. 60000592-60000603

Abstract

NaCl administration enhances HCO3 secretion in the distal tubule of animals with chronic metabolic alkalosis but does not correct the augmented H+ secretion characteristic of this disorder. The present studiesused in vivo microperfusion micropuncture to investigate whether combined repletion of K+ and Cl- corrected the augmented H+ secretion in the distal tubule of rats with chronic furosemide-induced metabolic alkalosis. Correction of alkalosis was induced in one group of animals with NaCl and in another group with a similar amount of Cl- as NaCl + KCl for 24 h; each group was compared with animals with maintained alkalosis. Total 24-h urine HCO3 excretion by each Cl--repleted group comprised greater than or equal to 70% of the calculated HCO3 loss necessary to induce the respective decrease in plasma total CO2. Alkalotic animals given NaCl + KCl had significantly lower H+ secretion in the distal tubule compared with animals with maintained alkalosis (15.5 +/- 1.2 vs. 34.6 +/- 1.8 pmol.mm(-1).min(-1), P < 0.01) but those given onlyNaCl did not (28.3 +/- 1.5 pmol.mm(-1).min(-1), P = 0.14). H+ secretion was not different among control animals given similar amounts of Na, K+, and Cl-. These studies demonstrate that Cl- repletion corrects chronic furosemide-induced metabolic alkalosis predominantly by a renal mechanism and that combined administration of K+ and Cl- but not of Cl- alone, corrects the augmented H+ secretion in the distal tubule inthis model of chronic alkalosis.

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Documento generato il 01/10/20 alle ore 15:13:57