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Titolo:
EFFECT OF MATERNAL GLUCOCORTICOID TREATMENT ON FETAL FLUIDS IN SHEEP AT 0.4 GESTATION
Autore:
WINTOUR EM; ALCORN D; MCFARLANE A; MORITZ K; POTOCNIK SJ; TANGALAKIS K;
Indirizzi:
UNIV MELBOURNE,HOWARD FLOREY INST EXPTL PHYSIOL & MED PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT ANAT & CELL BIOL PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
The American journal of physiology
fascicolo: 4, volume: 266, anno: 1994,
parte:, 2
pagine: 180001174 - 180001181
SICI:
0002-9513(1994)266:4<180001174:EOMGTO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLANTOIC COMPARTMENTS; OVINE FETUS; CORTISOL; BLOOD;
Keywords:
AMNIOTIC FLUID; ALLANTOIC FLUID; DEXAMETHASONE; OVINE FETUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Wintour et al., "EFFECT OF MATERNAL GLUCOCORTICOID TREATMENT ON FETAL FLUIDS IN SHEEP AT 0.4 GESTATION", The American journal of physiology, 266(4), 1994, pp. 180001174-180001181

Abstract

Treatment of nine pregnant Merino ewes (64.0 +/- 0.4 days of gestation) with dexamethasone (D; 0.76 mg/h for 48 h) resulted in significant alterations in fetal fluids compared with eight saline-infused controlanimals (S; 63.0 +/- 0.9 days). There was a substantial increase in allantoic fluid volume (177 +/- 18 ml, D vs. 31 +/- 6, S) but no changein amniotic fluid volume (248 +/- 12 ml, D; 305 +/- 24, S). For allantoic fluid there was a significant decrease in osmolality (213 +/- 4 mosmol/kg water, D; 230 +/- 5, S) and alterations in composition. Amniotic fluid osmolality was unchanged (292 +/- 2 mosmol/kg water, D; 293 /- 1, S), but amniotic fluid composition was affected. In four fetuses in which bladder and amniotic cannulas were inserted at gestational age 68-75 days, fetal urine flow rate increased from a mean of 4.1 +/-1.1 to 13.8 +/- 2.6 ml/h after 24 h and 11.8 +/- 3.0 ml/h at 48 h fora similar maternal D infusion, whereas no such increase occurred in four control fetuses. All the fetal urine voided during a 3.5- to 4-h infusion of Cr-51-labeled EDTA into the fetal bladder was directed to the allantois. The results suggest that the increase in allantoic fluidvolume resulted from increased fetal urine output into the allantoic compartment, although the composition of the excess allantoic fluid differed substantially from that of fetal urine. There was a greater incidence of abnormal cotyledons in the D-infused ewes. Altogether the findings suggest that if maternal glucocorticoids are increased by some stress early in pregnancy, there will be marked abnormalities in placental structure and in fetal fluids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:13:50