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Titolo:
INTRAARTERIAL INFUSION OF PAPAVERINE IN EXPERIMENTAL CEREBRAL VASOSPASM
Autore:
FUJIWARA N; HONJO Y; OHKAWA M; TANABE M; IRIE K; NAGAO S; TAKASHIMA H; SATOH K; KOJIMA K;
Indirizzi:
1750-1 IKENOBE MIKI KAGAWA 76107 JAPAN KAGAWA MED UNIV,DEPT RADIOL KAGAWA JAPAN KAGAWA MED UNIV,DEPT NEUROSURG KAGAWA JAPAN KAGAWA ROSAI HOSP,DEPT RADIOL KAGAWA JAPAN
Titolo Testata:
American journal of neuroradiology
fascicolo: 2, volume: 18, anno: 1997,
pagine: 255 - 262
SICI:
0195-6108(1997)18:2<255:IIOPIE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL SUBARACHNOID HEMORRHAGE; INTRACRANIAL ARTERIAL VASOSPASM; TRANSLUMINAL ANGIOPLASTY; UPDATE; HYPERTENSION; MANAGEMENT; PREVENTION; ANEURYSM; SPASM; DRUGS;
Keywords:
DRUGS, INTRAARTERIAL INFUSION; VASOSPASM; ANIMAL STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
N. Fujiwara et al., "INTRAARTERIAL INFUSION OF PAPAVERINE IN EXPERIMENTAL CEREBRAL VASOSPASM", American journal of neuroradiology, 18(2), 1997, pp. 255-262

Abstract

PURPOSE: To determine the effectiveness of intraarterial infusion of papaverine hydrochloride (PPV) in an experimental model of cerebral vasospasm and to measure the mean blood flow velocity of the middle cerebral artery (MCA), METHODS: Seven Japanese monkeys were divided into three groups: those studied 3 days after surgery (the third-day group, n = 3); those studied 7 days after surgery (the seventh-day group, n =3); and a control group (n = 1). Vasospasm was induced in the experimental groups by placing a blood clot in the subarachnoid space around the top of the internal carotid siphon, PPV (5 mg/kg) was infused (over 60 minutes) into the internal carotid artery (ICA). The vascular diameters of the ICA and MCA were measured on angiograms before and afterinfusion, The mean blood flow velocity in the MCA was measured on transcranial Doppler sonograms before and 24 hours after infusion, After fixation, the MCA was dissected out, stained, and examined microscopically. RESULTS: After vasospasm induction, both arteries were narrowed more than 30% in the third-day group and more than 50% in the seventh-day group. After PPV infusion in both groups, vascular dilatation of about 20% was seen. The mean increase in blood flow velocity in the third-day group (30%) was smaller than in the seventh-day group (70%). The mean blood flow velocity in the MCA decreased by about 30% in both groups, but increased again after 24 hours nearly to the level before PPV infusion, The intimal layer was more corrugated in the seventh-day group, and hypertrophy in the smooth muscle layer was also seen. Clinical examination showed no neurologic deficit in the third-day group 24hours after PPV infusion; neurologic deficits were observed in the seventh-day group. CONCLUSION: PPV infusion may be more effective in early stages of vasospasm when vascular walls have fewer histologic changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 10:25:49