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Titolo:
RADIOSENSITIVITY OF ATAXIA-TELANGIECTASIA, X-LINKED AGAMMAGLOBULINEMIA, AND RELATED SYNDROMES USING A MODIFIED COLONY SURVIVAL ASSAY
Autore:
HUE YK; WANG ZJ; HONG JH; CHESSA L; MCBRIDE WH; PERLMAN SL; GATTI RA;
Indirizzi:
UNIV CALIF LOS ANGELES,CTR HLTH SCI,SCH DENT,DEPT PATHOL,10833 LE CONTE AVE LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,CTR HLTH SCI,SCH DENT,DEPT PATHOL LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIAT ONCOL LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL LOS ANGELES CA 90024 UNIV ROMA LA SAPIENZA,DEPT EXPTL MED I-00185 ROME ITALY
Titolo Testata:
Cancer research
fascicolo: 10, volume: 54, anno: 1994,
pagine: 2544 - 2547
SICI:
0008-5472(1994)54:10<2544:ROAXA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIJMEGEN BREAKAGE SYNDROME; CHROMOSOMAL INSTABILITY DISORDER; IONIZING-RADIATION; SCID MUTATION; SENSITIVITY; COMPLEMENTATION; HETEROZYGOTES; LOCALIZATION; REPAIR; CELLS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
Y.K. Hue et al., "RADIOSENSITIVITY OF ATAXIA-TELANGIECTASIA, X-LINKED AGAMMAGLOBULINEMIA, AND RELATED SYNDROMES USING A MODIFIED COLONY SURVIVAL ASSAY", Cancer research, 54(10), 1994, pp. 2544-2547

Abstract

We used a modified colony survival assay to measure the sensitivity to ionizing radiation of more than 50 lymphoblastoid cell lines from normal individuals and from patients with ataxia-telangiectasia, Nijmegen breakage syndrome variants, and X-linked agammaglobulinemia. All of these disorders are associated with an increased frequency of cancer. Lymphoblastoid cell lines from patients with ataxia-telangiectasia complementation groups A, C, D, and E; AT(Fresno); Nijmegen breakage syndrome variants V1 and V2; and X-linked agammaglobulinemia showed markedradiosensitivity, whereas ataxia-telangiectasia heterozygotes were similar to controls. Friedreich's ataxia is not associated with increased cancer risk; lymphoblastoid cell lines from two such patients showednormal radiosensitivity. Taken together, these results suggest that some forms of X-ray sensitivity and cancer susceptibility share a common mechanism, such as an enzyme that is necessary both for the repair of radiation damage to DNA and for gene rearrangements during V(D)J recombination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:55:10