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Titolo:
GENE-EXPRESSION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN THE MESENTERIC-ARTERIES OF GENETICALLY HYPERTENSIVE RATS
Autore:
TAKEDA Y; MIYAMORI I; YONEDA T; IKI K; HATAKEYAMA H; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA 920 JAPAN
Titolo Testata:
Hypertension
fascicolo: 5, volume: 23, anno: 1994,
pagine: 577 - 580
SICI:
0194-911X(1994)23:5<577:GO1DIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOSTEROID 11-BETA-DEHYDROGENASE; MINERALOCORTICOID RECEPTOR; LOCALIZATION; PROTECTOR; LIQUORICE; BINDING; CLONING; TISSUES;
Keywords:
HYDROXYSTEROID DEHYDROGENASES; RNA, MESSENGER; RATS, INBRED; NOREPINEPHRINE; ADRENAL CORTEX HORMONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "GENE-EXPRESSION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN THE MESENTERIC-ARTERIES OF GENETICALLY HYPERTENSIVE RATS", Hypertension, 23(5), 1994, pp. 577-580

Abstract

11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) modulates the access of corticosteroids to their receptors and plays an important role in controlling blood pressure. We determined 11 beta-HSD activity and mRNA levels in the mesenteric arteries of genetically hypertensive rats, the Dahl salt-sensitive hypertensive rat, and compared them with Dahl salt-resistant and Sprague-Dawley rats. 11 beta-HSD activity was expressed as the percent conversion of [H-3]corticosterone to [H-3]11-dehydrocorticosterone. 11 beta-HSD activity was significantly decreased in the mesenteric arteries of 8-week-old Dahl salt-sensitive hypertensive rats (11.41 +/- 1.4%) compared with Dahl salt-resistant rats (17.4 /- 1.4%) or Sprague-Dawley rats (18.0 +/- 1.5%) of the same age (P < .05). There were no significant differences in 11 beta-HSD activity between 4-week-old Dahl salt-sensitive hypertensive and Dahl salt-resistant rats of the same age (15.3 +/- 1.3% and 15.1 +/- 1.9%, respectively). The concentration of 11 beta-HSD mRNA in the mesenteric arteries of 8-week-old Dahl salt-sensitive hypertensive rats was significantly lower than in Dahl salt-resistant or Sprague-Dawley rats of the same age (P < .05). There were no significant differences in the concentration of 11 beta-HSD mRNA in the mesenteric arteries of 4-week-old Dahl salt-sensitive hypertensive rats, Dahl salt-resistant rats, and Sprague-Dawley rats. These results indicate that 11 beta-HSD in the vascular wall may play a role in the pathogenesis of hypertension in this rat model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:25:40