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Titolo:
LINEAR-DEPENDENCE OF MUSCLE PHOSPHOCREATINE KINETICS ON OXIDATIVE CAPACITY
Autore:
PAGANINI AT; FOLEY JM; MEYER RA;
Indirizzi:
MICHIGAN STATE UNIV,DEPT PHYSIOL,GILTNER HALL E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT PHYSIOL E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT PHYS EDUC & EXERCISE SCI E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT RADIOL E LANSING MI 48824
Titolo Testata:
American journal of physiology. Cell physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 501 - 510
SICI:
0363-6143(1997)41:2<501:LOMPKO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; OXYGEN-CONSUMPTION; MAGNETIC-RESONANCE; RAT; METABOLISM; COST; TRANSITIONS; RESPIRATION; RESYNTHESIS; TURNOVER;
Keywords:
CONTROL OF RESPIRATION; RAT FAST-TWITCH SKELETAL MUSCLE; MITOCHONDRIAL CONTENT; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A.T. Paganini et al., "LINEAR-DEPENDENCE OF MUSCLE PHOSPHOCREATINE KINETICS ON OXIDATIVE CAPACITY", American journal of physiology. Cell physiology, 41(2), 1997, pp. 501-510

Abstract

The influence of muscle oxidative capacity on phosphocreatine (PCr) changes during and after stimulation was examined in the superficial (fast-twitch) section of rat gastrocnemius muscles. Muscle mitochondrialenzymes were increased in one group of rats by 8-10 wk of training ona running wheel (to a final regimen of 50 min/day at 38 m/min, 5 days/wk) and decreased in another group by chemical thyroidectomy [0.025% methimazole (MMI) in drinking water for 8 wk]. After these treatments,muscle citrate synthase activity was 179 and 29%, respectively, of that in corresponding control groups. Muscle PCr and pH were measured byP-31-nuclear magnetic resonance spectroscopy before, during, and after 8 min of isometric twitch stimulation at 0.33 Hz (MMI) or 0.75 Hz (trained) and 2 Hz. There was a significant linear correlation (r = 0.84, P < 0.01) between the rate constant for PCr recovery after submaximal stimulation (0.33 or 0.75 Hz) and citrate synthase activity. Within the control groups, there was a significant correlation (r = 0.72, P <0.01) between the rate constant for PCr recovery and intracellular pHat the end of stimulation. The results are quantitatively consistent with linear/quasilinear models of respiratory control by the cytoplasmic free energy of ATP hydrolysis but not with respiratory control by cytoplasmic ADP.

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Documento generato il 27/11/20 alle ore 02:06:31