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Titolo:
COCHLEAR FUNCTION AFTER SELECTIVE INNER HAIR CELL DEGENERATION INDUCED BY CARBOPLATIN
Autore:
TAKENO S; HARRISON RV; IBRAHIM D; WAKE M; MOUNT RJ;
Indirizzi:
HOSP SICK CHILDREN,DEPT OTOLARYNGOL,AUDITORY SCI LAB,555 UNIV AVE TORONTO M5G 1X8 ON CANADA HIROSHIMA UNIV,DEPT OTOLARYNGOL HIROSHIMA JAPAN UNIV TORONTO,DEPT PHYSIOL TORONTO ON CANADA
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 75, anno: 1994,
pagine: 93 - 102
SICI:
0378-5955(1994)75:1-2<93:CFASIH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIS-DIAMMINEDICHLOROPLATINUM NSC-119875; GUINEA-PIG; CLINICAL-EXPERIENCE; HEARING-LOSS; OTOTOXICITY; PLATINUM; CISPLATIN; POTENTIALS; RESPONSES; ANALOGS;
Keywords:
CARBOPLATIN; ORGAN OF CORTI; CHINCHILLA; COCHLEAR ACTION POTENTIALS; COCHLEAR MICROPHONICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Takeno et al., "COCHLEAR FUNCTION AFTER SELECTIVE INNER HAIR CELL DEGENERATION INDUCED BY CARBOPLATIN", Hearing research, 75(1-2), 1994, pp. 93-102

Abstract

The ototoxicity of carboplatin, a second generation anti-cancer agent, was examined using the chinchilla as an animal model. In animals treated with a clinical therapeutic dose (400 mg/m(2)), the dominant degenerative change is to inner hair cells (IHCs). This is in sharp contrast to most other ototoxic agents, which damage primarily the outer hair cells (OHCs). Functional changes to the cochlea have been evaluated in carboplatin treated subjects by recording cochlear action potentials (CAP) and cochlear microphonics (CM); cochlear lesions were evaluated using scanning electron microscopy. In carboplatin treated animals, CAP thresholds to tone-pip stimuli were elevated in proportion to IHC damage in corresponding cochlear regions. In contrast, CM amplitudes and 'thresholds' remained close to normal in most cases, reflecting thepreservation of OHCs in the basal turn. These results indicate a highdegree of independence between the inner and outer hair cell systems in the cochlear transduction mechanism. We suggest that this species-specific preparation with selective IHC loss will provide a valuable tool for studying, separately, the role of OHCs in both afferent and efferent cochlear function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 10:34:39