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Titolo:
PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY - A NONINVASIVE TECHNIQUE FOR THE STUDY OF OCCLUSIVE ARTERIAL LEG DISEASE AND PERIPHERAL VASODILATOR THERAPY
Autore:
WAHL DG; SIMON JP; ROBIN B; WALKER P; JOUANNY P; ESCANYE JM; PAILLE F; SCHMIDT C; BRUNOTTE F; ROBERT J; SCHMITT J;
Indirizzi:
HOP CENT,SERV MED H,29 AVE LATTRE TASSIGNY,CO 34 F-54035 NANCY FRANCE CHU NANCY,BIOCHEM & MICROBIOL LAB F-54000 NANCY FRANCE
Titolo Testata:
Angiology
fascicolo: 5, volume: 45, anno: 1994,
pagine: 367 - 376
SICI:
0003-3197(1994)45:5<367:PMS-AN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; METABOLIC-ACTIVITY; CALF MUSCLE; P-31 NMR; INSUFFICIENCY; EXERCISE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Wahl et al., "PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY - A NONINVASIVE TECHNIQUE FOR THE STUDY OF OCCLUSIVE ARTERIAL LEG DISEASE AND PERIPHERAL VASODILATOR THERAPY", Angiology, 45(5), 1994, pp. 367-376

Abstract

Using P-31 nuclear magnetic resonance spectroscopy of the calf muscle, the authors studied patients with peripheral arterial occlusive disease. They studied PCr depletion and intracellular pH during aerobic exercise in patients and controls. The phosphocreatine (PCr) index {[PCr] / ([PCr] + [Pi])} at rest was correlated with blood flow measured byplethysmography. During aerobic exercise a greater decrease in pH wasobtained in patients (p < 0.03). They also studied the work necessaryto reach a PCr index = 0.5 during ischemic exercise. This workload was lower in patients than in controls: 32.99 +/- 3.04 J vs 58.89 +/- 8.55 J, p < 0.05. After vasodilator therapy the workload was improved inpatients: 32.99 +/- 3.04 J vs 38.85 +/- 3.54 J, p < 0.05. These results suggest that therapy resulted in improved tissue perfusion in patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:34:38