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Titolo:
CHEMICAL CARCINOGENESIS IN THE NERVOUS-SYSTEM - PAST AND FUTURE
Autore:
SCHLEGEL J; STUMM G; MENNEL HD;
Indirizzi:
UNIV MARBURG,KLINIKUM LAHNBERGE,PATHOL MED CTR,DEPT NEUROPATHOL D-35043 MARBURG GERMANY UNIV MARBURG,KLINIKUM LAHNBERGE,PATHOL MED CTR,DEPT NEUROPATHOL D-35043 MARBURG GERMANY UNIV REGENSBURG,DEPT PATHOL W-8400 REGENSBURG GERMANY UNIV HEIDELBERG,INST PATHOL W-6900 HEIDELBERG GERMANY
Titolo Testata:
Experimental and toxicologic pathology
fascicolo: 8, volume: 45, anno: 1994,
pagine: 455 - 466
SICI:
0940-2993(1994)45:8<455:CCITN->2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; TYROSINE KINASE-ACTIVITY; NEU ONCOGENE; TRANSPLANTED TUMORS; SIGNAL TRANSDUCTION; POINT MUTATION; RAT; ETHYLNITROSOUREA; GENE; CHEMOTHERAPY;
Keywords:
EXPERIMENTAL TUMORS; NERVOUS SYSTEM; INDUCTION; MORPHOLOGY; DERIVED MODELS; ONCOGENE EXPRESSION; EXPERIMENTAL MODELS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
J. Schlegel et al., "CHEMICAL CARCINOGENESIS IN THE NERVOUS-SYSTEM - PAST AND FUTURE", Experimental and toxicologic pathology, 45(8), 1994, pp. 455-466

Abstract

The model of experimental tumors of the nervous system has greatly contributed to our understanding of growth and management of intracranial tumors, but has been somewhat neglected in the last years, because awealth of new data concerning oncogenic action came from viral oncogenesis. These new issues led to a much better insight into human tumor induction and promotion. Yet one example of the impact of oncogenic transformation stems from the ''neurooncogenic'' model: the discovery ofthe neu oncogene and its product as a putative differentiation receptor in the cell membrane of experimental Schwann cell derived tumors. In the light of this unique finding the history of the ''neurooncogenic'' model and the morphological and ''clinical'' result of tumors produced within the model are reviewed. There is a large open field for future investigation both in basic and applied science.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:28:13