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Titolo:
TESTOSTERONE ADMINISTRATION INCREASES ADRENAL-RESPONSE TO ADRENOCORTICOTROPIN
Autore:
POLDERMAN KH; GOOREN LJG; VANDERVEEN EA;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED,DIV ENDOCRINOL,POB 7057 1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED,DIV ENDOCRINOL 1007 MB AMSTERDAM NETHERLANDS
Titolo Testata:
Clinical endocrinology
fascicolo: 5, volume: 40, anno: 1994,
pagine: 595 - 601
SICI:
0300-0664(1994)40:5<595:TAIATA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC OVARY SYNDROME; ANDROGEN SECRETION; DEHYDROEPIANDROSTERONE SULFATE; NORMAL WOMEN; STEROIDOGENESIS; HIRSUTISM; CELLS; ACTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Polderman et al., "TESTOSTERONE ADMINISTRATION INCREASES ADRENAL-RESPONSE TO ADRENOCORTICOTROPIN", Clinical endocrinology, 40(5), 1994, pp. 595-601

Abstract

OBJECTIVE Various studies have demonstrated coexistence of ovarian and adrenal hyperandrogenism in women. This study was designed to determine whether testosterone can increase the response of the adrenal gland to stimulation by adrenocorticotrophin (ACTH). DESIGN Non-randomizedintervention in a university teaching hospital. PATIENTS Twenty androgen-treated female-to-male transsexual patients (10 ovariectomized and10 non-ovariectomized) and 10 normal female controls. MEASUREMENTS ACTH stimulation tests were performed in all subjects. Baseline values and the increase above baseline values after ACTH stimulation were assessed for cortisol and the adrenal androgens androstenedione, dehydroepiandrosterone and dehydroepiandrosterone-sulphate. RESULTS Increases in levels of cortisol, androstenedione and dehydroepiandrosterone afteradministration of ACTH were greater in testosterone-treated transsexual patients than controls. CONCLUSION We conclude that testosterone increases the response of the adrenal gland to stimulation by ACTH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:26:28