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Titolo:
SPECTROFLUOROMETRIC ANALYSIS OF CEFOXITIN IN PHARMACEUTICAL DOSAGE
Autore:
MURILLO JA; LEMUS JM; GARCIA LF;
Indirizzi:
UNIV CASTILLA LA MANCHA,DEPT ANALYT CHEM & FOOD TECHNOL E-13071 CIUDAD REAL SPAIN
Titolo Testata:
Talanta
fascicolo: 4, volume: 41, anno: 1994,
pagine: 557 - 563
SICI:
0039-9140(1994)41:4<557:SAOCIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINDAMYCIN; INFECTIONS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Murillo et al., "SPECTROFLUOROMETRIC ANALYSIS OF CEFOXITIN IN PHARMACEUTICAL DOSAGE", Talanta, 41(4), 1994, pp. 557-563

Abstract

A fluorescence method involving sample pre-treatment is investigated concerning the determination of cefoxitin. A fluorescent product is formed when samples containing cefoxitin are subjected to alkaline hydrolysis with 1.0 M sodium hydroxide and heated for 60 min at 90-degrees. The fluorescence is measured in ethanol/water medium (50% v/v) at approximately pH 2.0 provided by adding of 0.1 M hydrochloric acid. The fluorescence excitation and emission maxima were 317 and 400 nm, respectively. The quantitative range is between 0.020 and 1.40 mug/ml. A detection limit of 2 x 10(-3) mug/ml was round. The proposed method has been applied to the determination of cefoxitin in commercial injections, saline and glucosed physiological serum.

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Documento generato il 27/11/20 alle ore 16:08:38