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Titolo:
EFFECT OF ACUTE ADMINISTRATION OF PYRIDOSTIGMINE AND PIRENZEPINE ON ACTH, GROWTH-HORMONE AND CORTISOL SECRETION IN CUSHINGS AND IN OBESE PATIENTS
Autore:
TAGLIAFERRI M; SCACCHI M; DUBINI A; CAVAGNINI F;
Indirizzi:
UNIV MILAN,OSPED S LUCA,CTR AUXOL ITALIANO,CHAIR ENDOCRINOL 2,VIA SPAGNOLETTO 3 I-20145 MILAN ITALY UNIV MILAN,ITALIAN AUXOL CTR I-20145 MILAN ITALY UNIV MILAN,CHAIR ENDOCRINOL 2 I-20145 MILAN ITALY
Titolo Testata:
Neuro endocrinology letters
fascicolo: 2, volume: 16, anno: 1994,
pagine: 145 - 150
SICI:
0172-780X(1994)16:2<145:EOAAOP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-RELEASING HORMONE; CORTICOTROPIN; STIMULATION; RESPONSES; RAT; NORMALIZE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Tagliaferri et al., "EFFECT OF ACUTE ADMINISTRATION OF PYRIDOSTIGMINE AND PIRENZEPINE ON ACTH, GROWTH-HORMONE AND CORTISOL SECRETION IN CUSHINGS AND IN OBESE PATIENTS", Neuro endocrinology letters, 16(2), 1994, pp. 145-150

Abstract

The effects of pyridostigmine (PD) (120 mg p.o.) and pirenzepine (PZ)(75 mg p.o.) on GH and ACTH/cortisol secretion were studied in 12 obese and 5 Cushing's patients. PD did not alter plasma ACTH and cortisollevels while inducing, in the obese but not in Cushing's patients, a small but appreciable GH rise (p < 0.05 between GH values in the two groups). PZ was completely ineffective. These data seem to indicate that: a) both in Cushing's and in obese patients there is an impaired central cholinergic neurotransmission, the alteration being more pronounced in the former; b) cholinergic neuroregulation is not crucial for basal ACTH secretion in man.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:21:55