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Titolo:
EFFECT OF SEX STEROIDS ON HYPOTHALAMIC GABA
Autore:
LASAGA M; SEILICOVICH A; DELCARMENDIAZ M; PISERA D; DEBELJUK L; DUVILANSKI B;
Indirizzi:
UNIV BUENOS AIRES,FAC MED,CTR INVEST REPROD RA-1121 BUENOS AIRES ARGENTINA
Titolo Testata:
Neuro endocrinology letters
fascicolo: 2, volume: 16, anno: 1994,
pagine: 111 - 119
SICI:
0172-780X(1994)16:2<111:EOSSOH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; RAT ANTERIOR-PITUITARY; DECARBOXYLASE ACTIVITY; PROLACTIN-RELEASE; ESTRADIOL BENZOATE; GABAERGIC ACTIVITY; ESTROGEN; BRAIN; DOPAMINE; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Lasaga et al., "EFFECT OF SEX STEROIDS ON HYPOTHALAMIC GABA", Neuro endocrinology letters, 16(2), 1994, pp. 111-119

Abstract

Orchidectomy decreased gamma-aminobutyric acid (GABA) levels and the activity of glutamic acid decarboxylase (GAD) in the acurate/median eminence area (ARC/ME). The replacement treatment with estradiol benzoate (E2) or testosterone propionate (T) restored both paramenters back to the levels of the control intact rats. Dihydrotestosterone propionate (DHT) administration did not reverse the effect of castration. Hypophysectomy diminished GABA content and E2 and T treatments can not reverse this action. Administration of an antiserum to rat prolactin (PRL)blocked the stimulatory action of E2 on GABA concentration and GAD activity in the ARC/ME. Implants of anterior pituitaries or the combination of both grafting pituitaries and E2 administration increased GABA content in the ARC/ME and anterior pituitary glands. These results indicate that PRL may mediate the stimulatory effect of estrogen on ARC/ME GABA neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:38:11