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Titolo:
TYROSINE PHOSPHORYLATION OF A 58 KDA PROTEIN-INDUCED BY MORPHINE IN SK-N-SH CELLS
Autore:
NAKANO K; OSUGI T; KUO CH; HIGUCHI H; MIKI N;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT PHARMACOL,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 200, anno: 1994,
pagine: 797 - 801
SICI:
0006-291X(1994)200:2<797:TPOA5K>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT LOCUS COERULEUS; ADENYLATE-CYCLASE; INHIBITION; KINASE; BRAIN; ACTIVATION; EXPRESSION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K. Nakano et al., "TYROSINE PHOSPHORYLATION OF A 58 KDA PROTEIN-INDUCED BY MORPHINE IN SK-N-SH CELLS", Biochemical and biophysical research communications, 200(2), 1994, pp. 797-801

Abstract

A 58 kDa protein which was phosphorylated on tyrosine residues with morphine was found in human neuroblastoma cells (SK-N-SH cells) by immunoblot with monoclonal anti-phosphotyrosine antibody. The tyrosine phosphorylation was induced by morphine in 5 min in a dose-dependent manner and the increment was completely inhibited by naloxone. A Delta (d)agonist, [D-Pen(2),Pen(5)]-enkephalin (DPDPE), but not a m agonist, [D-Ala(2),N-Me-Phe,Gly(5)-ol] -enkephalin (DAGO), stimulated the phosphorylation and treatment of the cells with pertussis toxin inhibited the phosphorylation by morphine. These data suggest that d receptor-stimulation increases tyrosine phosphorylation of the 58 kDa protein through Gi protein in SK-N-SH cells. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:51:57