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Titolo:
A-68930, A NOVEL, POTENT DOPAMINE D1 RECEPTOR AGONIST - A MICROSTRUCTURAL ANALYSIS OF ITS EFFECTS ON FEEDING AND OTHER BEHAVIOR IN THE RAT
Autore:
ALNASER HA; COOPER SJ;
Indirizzi:
UNIV BIRMINGHAM,SCH PSYCHOL,PSYCHOPHARMACOL LAB BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM,SCH PSYCHOL,PSYCHOPHARMACOL LAB BIRMINGHAM B15 2TT W MIDLANDS ENGLAND
Titolo Testata:
Behavioural pharmacology
fascicolo: 2, volume: 5, anno: 1994,
pagine: 210 - 218
SICI:
0955-8810(1994)5:2<210:AANPDD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-INTAKE; APOMORPHINE ANOREXIA; D-AMPHETAMINE; N-0437; CONSUMPTION; D-1; SK-AND-F-38393; STIMULATION; INVOLVEMENT; ANTAGONISTS;
Keywords:
A-68930; DOPAMINE D1 RECEPTOR; FEEDING; GROOMING; LOCOMOTION; RAT; REARING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
H.A. Alnaser e S.J. Cooper, "A-68930, A NOVEL, POTENT DOPAMINE D1 RECEPTOR AGONIST - A MICROSTRUCTURAL ANALYSIS OF ITS EFFECTS ON FEEDING AND OTHER BEHAVIOR IN THE RAT", Behavioural pharmacology, 5(2), 1994, pp. 210-218

Abstract

A-68930 3S)-1-aminomethyI-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK&F 38393, reduced food consumption in rats and mice. The aim of this study was to undertake a microstructural analysis of the effects of A-68930 on food intake and feeding behaviour in non-deprived male rats trained to consume a highly palatable diet in a 20 min period. A-68930 (0.1-1.0 mg/kg, s.c.) produced a dose-dependent reduction in food intake, which was due to a reduction in the frequency of bouts of feeding but not to a reduction in bout duration. A-68930 had little effect on the latency toinitiate feeding or on the local rate of eating. Hence, it had a selective action on the parameters of eating, which is distinctly different from the effects of selective D2 agonists or of indirectly acting psychomotor stimulants like cocaine. A-68930 also increased grooming by lengthening the grooming bouts, and reduced locomotion and rearing responses. At the largest dose, immobility was increased, The anorectic effect of A-68930 may reflect, at least in part, the increased groomingit produces.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:57:22