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Titolo:
IN-VIVO AND IN-VITRO EFFECTS OF DIISOPROPYL PHOSPHOROFLUORIDATE (DFP)ON THE RATE OF HEN BRAIN TUBULIN POLYMERIZATION
Autore:
GUPTA RP; ABOUDONIA MB;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PHARMACOL,POB 3813 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT PHARMACOL DURHAM NC 27710
Titolo Testata:
Neurochemical research
fascicolo: 4, volume: 19, anno: 1994,
pagine: 435 - 444
SICI:
0364-3190(1994)19:4<435:IAIEOD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLATED ALPHA-TUBULIN; MICROTUBULE-ASSOCIATED PROTEINS; INDUCED DELAYED NEUROTOXICITY; SYNTHETIC PEPTIDE; NEUROFILAMENT; PHOSPHORYLATION; 2,5-HEXANEDIONE; KINASE; TAU; LOCALIZATION;
Keywords:
TUBULIN; TAU, DIISOPROPYL PHOSPHOROFLUORIDATE (DFP), HEN BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Gupta e M.B. Aboudonia, "IN-VIVO AND IN-VITRO EFFECTS OF DIISOPROPYL PHOSPHOROFLUORIDATE (DFP)ON THE RATE OF HEN BRAIN TUBULIN POLYMERIZATION", Neurochemical research, 19(4), 1994, pp. 435-444

Abstract

Diisopropyl phorphorofluoridate (DFP) produces organophosphorus ester-induced delayed neurotoxicity (OPIDN) in sensitive species. We have investigated the in vivo and in vitro effects of DFP on hen brain tubulin polymerization. Hens were treated with a single dose of DFP (1.7 mg/kg, sc.), and were sacrificed after 18-21 days. Tubulin from DFP-treated hen brains showed small but significant decrease (14.42%) in the rate of polymerization and 11.05% decrease in rise in O.D. at 340 nm in30 min. DFP in vivo treatment also resulted in decreased concentration of tan and an enhanced concentration of two peptides (45 kDa, 35 kDa) in the brain supernatant. These peptides seemed to be the degradation products of MAP-2. The decrease in the rate of brain tubulin polymerization in treated hens is consistent with neurochemical alterations and the focal degeneration and aggregation of these filamentous structures in OPIDN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:53:54