Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXPERIMENTAL STUDIES OF COMPETITION BETWEEN ENANTIOMERS IN CHIRAL LIQUID-CHROMATOGRAPHY THROUGH THEIR SYSTEM PEAKS
Autore:
LEVIN S; ABULAFI S;
Indirizzi:
HEBREW UNIV JERUSALEM,SCH PHARM,DEPT PHARMACEUT CHEM,POB 12065 IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Chirality
fascicolo: 2, volume: 6, anno: 1994,
pagine: 148 - 155
SICI:
0899-0042(1994)6:2<148:ESOCBE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATIONARY PHASES; ADSORPTION-ISOTHERMS; SEPARATION; COLUMN; MIXTURES; PHENYLALANINE; RECOGNITION; COMPONENTS; EXCESS;
Keywords:
CHIRAL STATIONARY PHASE; DINITROBENZYLPHENYLETHYLAMINE; DINITROBENZOYLPHENYLGLYCINE; ENANTIOMERS; 2,2,2-TRIFLUORO-1-(9-ANTHRYL) ETHANOL; COMPETITION; NONLINEAR; LIQUID CHROMATOGRAPHY; SYSTEM PEAKS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Levin e S. Abulafi, "EXPERIMENTAL STUDIES OF COMPETITION BETWEEN ENANTIOMERS IN CHIRAL LIQUID-CHROMATOGRAPHY THROUGH THEIR SYSTEM PEAKS", Chirality, 6(2), 1994, pp. 148-155

Abstract

Competition between the (+)- and (-) enantiomers of 2,2,2-trifluoro-1-(9-anthryl) ethanol as mobile phase additives was indicated by the chromatographic behavior of their system peaks. Two types of chiral stationary phases were used, one based on dinitrobenzoylphenylglycine and the other on dinitrobenzylphenylethylamine plus tartaric acid. The racemic mixture was used as the mobile phase additive and k' of their system peaks was studied as a function of the mixture concentration in the mobile phase in both cases. A shift in k' of the two system peaks was observed and considered as an indication that competition occurred. The areas of the two system peaks were also studied as a function of the concentration of the enantiomers in the samples, using two different compositions of the mobile phase. The dependency of system peaks' area on the sample composition indicated whether competition between theenantiomers occurred. One mobile phase contained 0.1 mM of the racemic mixture, where the area of the two retained system peaks behaved independently, i.e., only the peak corresponding to the enantiomer was affected by its presence in the sample. The other mobile phase contained0.75 mM of the racemic mixture, and both peaks were affected by the injection of any one of the enantiomers. The interdependency of the system peaks' area on both the enantiomers indicated that their distribution in the chiral system was interrelated due to mutual interactions. A quantitative treatment of the interdependency and competition was excluded, due to the irreversible adsorption of the two enantiomers on the chiral stationary phase after using overloading concentrations. This irreversible adsorption was visualized by the appearance of two retained system peaks of the two residual enantiomers. These system peaks were detected only when the sample contained pure enantiomers due to competition between the enantiomer in the sample with the residual enantiomers in the stationary phase. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:34:50