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Titolo:
INITIAL CHARACTERIZATION OF THE DOSIMETRY AND RADIOBIOLOGY OF A DEVICE FOR ADMINISTERING INTERSTITIAL STEREOTAXIC RADIOSURGERY
Autore:
HAKIM R; ZERVAS NT; HAKIM F; BUTLER WE; BEATTY J; YANCH JC; BIGGS PJ; GALL KP; SLISKI AP;
Indirizzi:
MASSACHUSETTS GEN HOSP,NEUROSURG SERV,WHITE 502,55 FRUIT ST BOSTON MA02114 MASSACHUSETTS GEN HOSP,NEUROSURG SERV BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT RADIAT MED BOSTON MA 02114 PHOTOELECTRON CORP LEXINGTON MA 00000 MIT,DEPT NUCL ENGN CAMBRIDGE MA 02139
Titolo Testata:
Neurosurgery
fascicolo: 3, volume: 40, anno: 1997,
pagine: 510 - 516
SICI:
0148-396X(1997)40:3<510:ICOTDA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Keywords:
DOSIMETRY; INTERSTITIAL RADIATION; RADIOBIOLOGY; RADIOSURGERY; STEREOTAXY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
R. Hakim et al., "INITIAL CHARACTERIZATION OF THE DOSIMETRY AND RADIOBIOLOGY OF A DEVICE FOR ADMINISTERING INTERSTITIAL STEREOTAXIC RADIOSURGERY", Neurosurgery, 40(3), 1997, pp. 510-516

Abstract

OBJECTIVE: We report the design and initial characterization of the dosimetry and radiobiology of a novel device for interstitial stereotactic radiosurgery.INSTRUMENTATION: The device is lightweight, handheld,and battery-powered, and it emits x-ray radiation from the tip of a probe 3 mm in diameter by 10 cm in length. METHODS: The dosimetry was characterized by two independent methods: thermoluminescent dosimeters and radiochromic film. The radiobiology was characterized by in vivo irradiation of rat liver, dog liver, and dog brain. The animals were killed at varying intervals of time, and histological examinations were performed. Heat transfer from the probe to dog brain was studied in vivo by placing thermocouple sensors around the probe tip before irradiating. RESULTS: Both dosimetric methods showed a steep dose-distance fall-off relationship (proportional to the reciprocal of the cube of thedistance from the probe tip). Rats and dogs that were killed weeks tomonths after liver irradiation tended to have sharply demarcated lesions. Liver enzyme levels, measured serially in the dogs, did not give evidence of chronic inflammation. Histological examination of the brains of dogs that were killed acutely after irradiation did not show evidence of inflammation, edema, or hemorrhage. The tissue temperature elevation 1 cm from the tip never exceeded 0.5 degrees C, thereby excluding hyperthermia as a significant contributor to the formation of lesions. CONCLUSIONS: Because this device requires relatively few supporting resources, has sharp dosimetric properties, and seems to be safe, it may be useful as a clinical tool for interstitial stereotactic radiosurgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 10:21:25