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Titolo:
BORNA-DISEASE VIRUS-SPECIFIC T-CELLS PROTECT AGAINST OR CAUSE IMMUNOPATHOLOGICAL BORNA-DISEASE
Autore:
RICHT JA; SCHMEEL A; FRESE K; CARBONE KM; NARAYAN O; ROTT R;
Indirizzi:
UNIV GIESSEN,INST VIROL,FRANKFURTER STR 107,LABOR 235 D-35392 GIESSENGERMANY UNIV GIESSEN,INST VET PATHOL D-35392 GIESSEN GERMANY JOHNS HOPKINS UNIV,SCH MED BALTIMORE MD 21205
Titolo Testata:
The Journal of experimental medicine
fascicolo: 5, volume: 179, anno: 1994,
pagine: 1467 - 1473
SICI:
0022-1007(1994)179:5<1467:BVTPAO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOIMMUNE ENCEPHALOMYELITIS; RATS; INFECTION; BRAIN; MENINGOENCEPHALOMYELITIS; VACCINATION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Richt et al., "BORNA-DISEASE VIRUS-SPECIFIC T-CELLS PROTECT AGAINST OR CAUSE IMMUNOPATHOLOGICAL BORNA-DISEASE", The Journal of experimental medicine, 179(5), 1994, pp. 1467-1473

Abstract

In this report we show that passive immunization of Lewis rats with viable CD4(+), Borna disease virus (BDV)-specific T cells before infection with BDV resulted in protection against BD, whereas inoculation ofthese T cells after BDV infection induced clinical disease with more rapid onset than seen in BDV control animals. The protective as well as encephalitogenic effector functions of BDV-specific CD4(+) T cells were mediated only by viable BDV-specific T cells. The protective situation was obtained by passive transfer of BDV-specific T cells into animals inoculated later with virus, whereas the immunopathological situation was observed when virus-specific T cells developed normally or after adoptive transfer, and appeared on the scene after considerable virus replication in the brain.

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Documento generato il 21/01/20 alle ore 01:06:15