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Titolo:
MOLECULAR-CLONING AND FUNCTIONAL ANAL OF THE ADENOVIRUS E1A-ASSOCIATED 300-KD PROTEIN (P300) REVEALS A PROTEIN WITH PROPERTIES OF A TRANSCRIPTIONAL ADAPTER
Autore:
ECKNER R; EWEN ME; NEWSOME D; GERDES M; DECAPRIO JA; LAWRENCE JB; LIVINGSTON DM;
Indirizzi:
DANA FARBER CANC INST BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115 UNIV MASSACHUSETTS,MED CTR,DEPT CELL BIOL WORCESTER MA 01655
Titolo Testata:
Genes & development
fascicolo: 8, volume: 8, anno: 1994,
pagine: 869 - 884
SICI:
0890-9369(1994)8:8<869:MAFAOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
E1A PROTEINS; CELL-CYCLE; DROSOPHILA-TRITHORAX; TERMINAL REGION; ACUTE LEUKEMIAS; DNA-SYNTHESIS; GENE; DOMAINS; REPRESSION; EXPRESSION;
Keywords:
P300; TRANSCRIPTIONAL ADAPTER PROTEIN; E1A-BINDING PROTEIN; CELL CYCLE REGULATORY PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
R. Eckner et al., "MOLECULAR-CLONING AND FUNCTIONAL ANAL OF THE ADENOVIRUS E1A-ASSOCIATED 300-KD PROTEIN (P300) REVEALS A PROTEIN WITH PROPERTIES OF A TRANSCRIPTIONAL ADAPTER", Genes & development, 8(8), 1994, pp. 869-884

Abstract

The growth-controlling functions of the adenovirus E1A oncoprotein depend on its ability to interact with a set of cellular proteins. Amongthese are the retinoblastoma protein, p107, p130, and p300. We have isolated a cDNA encoding full-length human p300 and mapped the chromosomal location of the gene to chromosome 22q13. p300 contains three cysteine- and histidine-rich regions of which the most carboxy-terminal region interacts specifically with E1A. In its center, p300 contains a bromodomain, a hallmark of certain transcriptional coactivators. We have examined the ability of p300 to overcome the repressive effect of E1A on the SV40 enhancer. We show that p300 molecules lacking an intact E1A-binding site can bypass E1A repression and restore to a significant extent the activity of the SV40 enhancer, even in the presence of high levels of E1A protein. These results imply that p300 may function as a transcriptional adaptor protein for certain complex transcriptional regulatory elements.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:18:18