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Titolo:
THE VASCULAR-RESPONSE IN CHRONIC PERIODONTITIS
Autore:
ZOELLNER H; HUNTER N;
Indirizzi:
UNIV VIENNA,DEPT MED PHYSIOL,SCHWARZSPANIERSTR 17 A-1090 VIENNA AUSTRIA
Titolo Testata:
Australian dental journal
fascicolo: 2, volume: 39, anno: 1994,
pagine: 93 - 97
SICI:
0045-0421(1994)39:2<93:TVICP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Keywords:
ENDOTHELIUM; GINGIVITIS; HYALINE MATERIAL; HIGH ENDOTHELIUM; PERIODONTITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
H. Zoellner e N. Hunter, "THE VASCULAR-RESPONSE IN CHRONIC PERIODONTITIS", Australian dental journal, 39(2), 1994, pp. 93-97

Abstract

The role of vascular endothelial cells (EC) in periodontitis was investigated in a series of histological studies. Expansion of the vasculature was found to occur with development of gingivitis and periodontitis. This was thought to contribute to the characteristic tissue degradation in the developing disease. Vascular expansion could also play a role in the formation of a previously unreported perivascular hyaline material (PHyM). Polymorphonuclear leukocytes (PMN) are known to be protective in periodontitis, and the location, incidence and extent of PHyM suggested a role for PHyM in periodontitis by inhibiting PMN emigration. PMN emigration was found to occur from specialized high EC (HEC) lined post capillary venules. This was unexpected, as such vessels have previously been found to exchange lymphocytes almost exclusively. Detailed histochemical, ultrastructural and biosynthetic studies of these specialized blood vessels led to the suggestion that HEC may be specially adapted for the synthesis of cytokines in periodontitis. A negative association between expression of the membrane bound ectoenzyme,alkaline phosphatase, and HEC suggested a role for this enzyme in leukocyte emigration. These observations compel re-evaluation of the roleof EC in chronic inflammation, and in periodontitis in particular. The direction of current and future work is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:51:08