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Titolo:
ROLE OF GROWTH-HORMONE IN OVARIAN PHYSIOLOGY AND ONSET OF PUBERTY
Autore:
SHARARA FI; GIUDICE LC;
Indirizzi:
UNIV MARYLAND,SCH MED,DEPT OBSTET GYNECOL & REPROD SCI,DIV REPROD ENDOCRINOL & INFERTIL BALTIMORE MD 20201 STANFORD UNIV,DEPT GYNECOL & OBSTET,DIV REPROD ENDOCRINOL & INFERTIL STANFORD CA 00000
Titolo Testata:
Journal of the Society for Gynecologic Investigation
fascicolo: 1, volume: 4, anno: 1997,
pagine: 2 - 7
SICI:
1071-5576(1997)4:1<2:ROGIOP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
I IGF-I; SOMATOMEDIN-C CONCENTRATIONS; TRUE PRECOCIOUS PUBERTY; LARON-TYPE DWARFISM; BINDING-PROTEIN; CHORIONIC SOMATOMAMMOTROPIN; FOLLICULAR DEVELOPMENT; LUTEINIZING-HORMONE; SECRETORY DYNAMICS; PREPUBERTAL GIRLS;
Keywords:
GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR-I; PUBERTY; GH DEFICIENCY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
F.I. Sharara e L.C. Giudice, "ROLE OF GROWTH-HORMONE IN OVARIAN PHYSIOLOGY AND ONSET OF PUBERTY", Journal of the Society for Gynecologic Investigation, 4(1), 1997, pp. 2-7

Abstract

OBJECTIVE: To review the role of growth hormone (GH) in the timing ofpuberty and to summarize the interactions between the somatotrophic and reproductive axes. The use of recombinant GH in patients with GH deficiency is outlined. METHODS: A MEDLINE search was performed of English language manuscripts dealing with the role or use of GH in puberty and reproduction. RESULTS: Growth hormone appears to augment the rate of sexual maturation once a pubertal pattern of gonadotropin secretionis established. Growth hormone may modulate gonadal steroid production by increasing hepatic insulin-like growth factor-I production or by acting directly on GH receptors, localized recently in the granulosa cells and corpus luteum in the human ovary. Patients with isolated GH deficiency exhibit short stature, truncal adiposity, and delayed puberty. However, patients with isolated GH deficiency ultimately undergo spontaneous puberty, and women with GH receptor defects are fertile, suggesting that GH most likely acts as a co-gonadotropin to augment the actions of FSH and LH on estradiol and progesterone production. CONCLUSIONS: Growth hormone appears to increase the rate of sexual maturationonce a pubertal pattern of pituitary gonadotropin secretion is established. The ovary is a site of GH reception and action, where it can potentiate steroidogenesis and gametogenesis either directly or through endocrine actions. Continued basic and clinical research is needed to characterize further the role of GH in reproductive physiology. Copyright (C) 1997 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:56:20