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Titolo:
MODULATION OF THE IMMUNE-RESPONSE IN MULTIPLE-SCLEROSIS - PRODUCTION OF MONOCLONAL-ANTIBODIES SPECIFIC TO HLA MYELIN BASIC-PROTEIN/
Autore:
PURI J; ARNON R; GUREVICH E; TEITELBAUM D;
Indirizzi:
WEIZMANN INST SCI,DEPT IMMUNOL,POB 26 IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT IMMUNOL IL-76100 REHOVOT ISRAEL TEL AVIV UNIV IL-69978 TEL AVIV ISRAEL KUPAT CHOLIM CLALIT,DEPT FAMILY MED TEL AVIV ISRAEL
Titolo Testata:
The Journal of immunology
fascicolo: 5, volume: 158, anno: 1997,
pagine: 2471 - 2476
SICI:
0022-1767(1997)158:5<2471:MOTIIM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; T-CELL RECOGNITION; PROTEOLIPID PROTEIN; PEPTIDE COMPLEXES; LYMPHOCYTE-T; RECEPTOR; FREQUENCY; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J. Puri et al., "MODULATION OF THE IMMUNE-RESPONSE IN MULTIPLE-SCLEROSIS - PRODUCTION OF MONOCLONAL-ANTIBODIES SPECIFIC TO HLA MYELIN BASIC-PROTEIN/", The Journal of immunology, 158(5), 1997, pp. 2471-2476

Abstract

Monoclonal Abs to the complex formed between human MHC class II molecules (DR7 and DRw11) and myelin basic protein (MBP) were produced. Thespecificity of these Abs was established by both FAGS analysis and complement-mediated cytotoxicity of MBP- or OVA-pulsed human APC of the same or of different DR restriction. These Abs bound to and lysed onlyMBP-pulsed human APC of the same DR restriction (DR7 or DRw11) but not to APC of different DR restriction or pulsed with a dofferemt Ag (OVA), The physiologic role of these Abs was further investigated. They blocked the in vitro proliferative response to MBP-specific T cell clones isolated from multiple sclerosis patients in an antigen-specific and DR-restricted manner. However, the Abs did not affect the response of MBP-specific T cell clones of other DR restriction nor did they interfere with the response to other Ags (purified protein derivative or copolymer 1) presented on APC with the same DR restriction. These Abs may be useful for treating multiple sclerosis in which reactivity to MBP is implicated. Moreover, this approach may be extended to other autoantigens and their counterpart autoimmune diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:06:13