Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LACK OF TYPE-2 T-CELL-INDEPENDENT B-CELL RESPONSES AND DEFECT IN ISOTYPE SWITCHING IN TNF-LYMPHOTOXIN ALPHA-DEFICIENT MICE
Autore:
RYFFEL B; DIPADOVA F; SCHREIER MH; LEHIR M; EUGSTER HP; QUESNIAUX VFJ;
Indirizzi:
UNIV BASEL,INST PATHOL,SCHONBEINSTR 40 CH-4031 BASEL SWITZERLAND SANDOZ PHARMA,PRECLIN RES BASEL SWITZERLAND SWISS FED INST TECHNOL,INST TOXICOL SCHWERZENBACH SWITZERLAND
Titolo Testata:
The Journal of immunology
fascicolo: 5, volume: 158, anno: 1997,
pagine: 2126 - 2133
SICI:
0022-1767(1997)158:5<2126:LOTTBR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; TRANSGENIC MICE; HETEROMERIC COMPLEX; CD40-DEFICIENT MICE; IMMUNE-RESPONSES; CD40 LIGAND; BETA; RECEPTOR; MONOCYTOGENES; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
B. Ryffel et al., "LACK OF TYPE-2 T-CELL-INDEPENDENT B-CELL RESPONSES AND DEFECT IN ISOTYPE SWITCHING IN TNF-LYMPHOTOXIN ALPHA-DEFICIENT MICE", The Journal of immunology, 158(5), 1997, pp. 2126-2133

Abstract

TNF is implicated in in vitro Ig production, but its role in vivo is not clearly defined. Our previous studies had shown that TNF-LT alpha double-deficient mice have defective IgM and IgG primary Ab responses to the T cell-dependent (TD) Ag SRBC. We now extend these studies to secondary responses and to T cell-independent (TI) B cell responses. Injections of the TD Ag SRBC did not induce germinal center formation inthe spleen of TNF-LT alpha-deficient mice. Associated with the morphologic defect, there was a defective Ige Ab response and a secondary hyper-IgM response to the TD Ag in TNF-LT alpha-deficient mice. The response to the TI Ag type 2 DNP-alanyl-glycyl-glycyl-ficoll was essentially absent in TNF-LT alpha-deficient mice, while that to the TI Ag type1 TNP-LPS was significantly reduced only for IgG2b isotype. Transplantation of bone marrow cells from wild-type mice into irradiated TNF-LTalpha-deficient mice restored the formation of splenic germinal centers and corrected the IgM and Ige responses to both TD and TI Ags. These data suggest that TNF and/or LT alpha signaling are critically required for germinal center formation and for the IgM and IgG responses toboth TD and TI type 2 Ags.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:57:31