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Titolo:
QUANTITATIVE-ANALYSES OF CELL BEHAVIORS UNDERLYING NOTOCHORD FORMATION AND EXTENSION IN MOUSE EMBRYOS
Autore:
SAUSEDO RA; SCHOENWOLF GC;
Indirizzi:
UNIV UTAH,SCH MED,DEPT NEUROBIOL & ANAT,50 N MED DR SALT LAKE CITY UT84132 UNIV UTAH,SCH MED,DEPT NEUROBIOL & ANAT SALT LAKE CITY UT 84132
Titolo Testata:
The Anatomical record
fascicolo: 1, volume: 239, anno: 1994,
pagine: 103 - 112
SICI:
0003-276X(1994)239:1<103:QOCBUN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
XENOPUS-LAEVIS; NEURAL PLATE; FATE;
Keywords:
CELL REARRANGEMENT; CONVERGENT-EXTENSION; GASTRULATION; GROWTH; HENSENS NODE; MESODERM; MITOSIS; MITOTIC SPINDLES; NEURULATION; PRIMITIVE STREAK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Sausedo e G.C. Schoenwolf, "QUANTITATIVE-ANALYSES OF CELL BEHAVIORS UNDERLYING NOTOCHORD FORMATION AND EXTENSION IN MOUSE EMBRYOS", The Anatomical record, 239(1), 1994, pp. 103-112

Abstract

Background: Formation and extension of the notochord (i.e., notogenesis) is one of the earliest and most obvious events of axis developmentin vertebrate embryos. In birds and mammals, prospective notochord cells arise from Hensen's node and come to lie beneath the midline of the neural plate. Throughout the period of neurulation, the notochord retains its close spatial relationship with the developing neural tube and undergoes rapid extension in concert with the overlying neuroepithelium. Methods: In the present study, we examined notochord developmentquantitatively in mouse embryos. C57BL/6 mouse embryos were collectedat 8, 8.5, 9, 9.5, and 10 days of gestation. They were then embedded in paraffin and sectioned transversely. Serial sections from 21 embryos were stained with Schiff's reagent according to the Feulgen-Rossenbeck procedure and used for quantitative analyses of notochord extension. Results: Quantitative analyses revealed that extension of the notochord involves cell division within the notochord proper and cell rearrangement within the notochordal plate (the immediate precursor of the notochord). In addition, extension of the notochord involves cell accretion, that is, the addition of cells to the notochord's caudal end, a process that involves considerable cell rearrangement at the notochordal plate-node interface. Conclusions: Extension of the mouse notochordoccurs similarly to that described previously for birds (Sausedo and Schoenwolf, 1993 Anat. Rec. 237:58-70). That is, in both birds (i.e., quail and chick) and mouse embryos, notochord extension involves cell division, cell rearrangement, and cell accretion. Thus higher vertebrates utilize similar morphogenetic movements to effect notogenesis. (C)1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:37:08